INT220592

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.22
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
neuronal 4
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 29 99.86 Very High Very High Very High
Hippocampus 41 77.44 Quite High
cerebral cortex 11 35.72 Quite Low
Nerve growth factor 3 22.24 Low Low
Inflammation 51 5.00 Very Low Very Low Very Low
Central nervous system 27 5.00 Very Low Very Low Very Low
Peripheral nervous system 24 5.00 Very Low Very Low Very Low
cINOD 21 5.00 Very Low Very Low Very Low
cytokine 17 5.00 Very Low Very Low Very Low
sodium channel 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 174 100.00 Very High Very High Very High
Alzheimer's Dementia 136 100.00 Very High Very High Very High
Cv Unclassified Under Development 24 99.86 Very High Very High Very High
Apoptosis 61 98.64 Very High Very High Very High
Disease 543 98.56 Very High Very High Very High
Death 38 95.96 Very High Very High Very High
Amyloid Plaque 55 89.56 High High
Toxicity 10 88.24 High High
Disease Progression 13 86.00 High High
Stress 205 74.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the rat ischemia model, this reduction in GGA3 levels was co-ordinated with caspase activation and increased BACE1 protein levels.
Negative_regulation (reduction) of Positive_regulation (activation) of BACE1 protein associated with ischemia
1) Confidence 0.42 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.01 Pain Relevance 0.14
In the rat model of ischemia, this reduction in GGA3 levels was co-ordinated with caspase activation and increased BACE1 protein levels.
Negative_regulation (reduction) of Positive_regulation (activation) of BACE1 protein associated with ischemia
2) Confidence 0.42 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.93 Pain Relevance 0.14
induced by Sal 003, a specific inhibitor of its phosphatase, elevates BACE1 levels in younger 5XFAD mice, which have not yet showed BACE1 upregulation at basal levels concomitant with only marginal increases in eIF2?
Neg (not) Negative_regulation (showed) of Neg (not) Positive_regulation (upregulation) of BACE1
3) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.49 Pain Relevance 0.08
Given the elevation of BACE1 around A?
Negative_regulation (Given) of Positive_regulation (elevation) of BACE1
4) Confidence 0.37 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.92 Pain Relevance 0
Importantly, because the BACE1 increase correlated with amyloid pathology in both Tg models and was observed in both the absence (Tg2576) and presence (5XFAD) of significant neuronal loss, we concluded that BACE1 elevation appeared to be associated with amyloid pathology rather than cell death.
Negative_regulation (observed) of Positive_regulation (increase) of BACE1 in neuronal associated with targeted disruption, alzheimer's dementia and death
5) Confidence 0.37 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.80 Pain Relevance 0
Importantly, because the BACE1 increase correlated with amyloid pathology in both Tg models and was observed in both the absence (Tg2576) and presence (5XFAD) of significant neuronal loss, we concluded that BACE1 elevation appeared to be associated with amyloid pathology rather than cell death.
Negative_regulation (observed) of Positive_regulation (increase) of BACE1 in neuronal associated with targeted disruption, alzheimer's dementia and death
6) Confidence 0.37 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 1.06 Pain Relevance 0

General Comments

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