INT220594

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Context Info
Confidence 0.79
First Reported 2007
Last Reported 2011
Negated 6
Speculated 0
Reported most in Body
Documents 48
Total Number 48
Disease Relevance 20.22
Pain Relevance 4.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
tail 3
adult mouse 2
neuronal 2
Neurons 2
primary neurons 1
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.2 96 98.60 Very High Very High Very High
cINOD 216 98.32 Very High Very High Very High
Central nervous system 209 98.20 Very High Very High Very High
Peripheral nervous system 190 97.88 Very High Very High Very High
cytokine 144 96.84 Very High Very High Very High
Inflammation 427 96.44 Very High Very High Very High
Inflammatory mediators 3 94.28 High High
hyperexcitability 24 93.96 High High
sodium channel 154 92.12 High High
antagonist 66 90.44 High High
Disease Link Frequency Relevance Heat
Disease 3464 99.80 Very High Very High Very High
Targeted Disruption 1340 99.68 Very High Very High Very High
Apoptosis 477 98.60 Very High Very High Very High
Amyloid Plaque 403 98.04 Very High Very High Very High
Convulsion 289 97.48 Very High Very High Very High
INFLAMMATION 550 96.44 Very High Very High Very High
Hypercholesterolemia 114 95.60 Very High Very High Very High
Alzheimer's Dementia 1028 94.48 High High
Death 312 93.24 High High
Congenital Anomalies 149 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACE-Cat1-immunostaining showed the neuronal localization of BACE1, with BACE1 immunoreactivity surrounding A?
Localization (localization) of BACE1 in neuronal
1) Confidence 0.79 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.65 Pain Relevance 0
The subcellular trafficking and localization of BACE1 can impact the activity of this enzyme significantly.
Localization (localization) of BACE1
2) Confidence 0.79 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.48 Pain Relevance 0.09
The intracellular trafficking and localization of the BACE1 protein is largely controlled by targeting signals present in the cytosolic portion of the C-terminal tail [235].
Localization (localization) of BACE1 protein in tail
3) Confidence 0.79 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.06 Pain Relevance 0
Further data about the subcellular trafficking and localization of BACE1 is detailed later.
Localization (localization) of BACE1
4) Confidence 0.79 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
To circumvent these issues we used the mono-specific BACE-Cat1 antibody and observed the neuronal localization of BACE1, with BACE1 immunoreactivity surrounding A?
Localization (localization) of BACE1 in neuronal
5) Confidence 0.79 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.83 Pain Relevance 0
Indeed, various types of lipid stimulate BACE1 activity and the raft localization of BACE1 may be enhanced by palmitoylation [115].
Localization (localization) of BACE1
6) Confidence 0.79 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.06 Pain Relevance 0
These data suggest that the ablation of a single BACE1 allele is not sufficient to prevent BACE1-elevating mechanisms, thus maintaining wild-type levels of this enzyme (i.e., twice the gene copy number) in BACE1+/?
Localization (allele) of BACE1
7) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.16 Pain Relevance 0
TaqMan qPCR primers were utilized for mouse BACE1 mRNA (Mm00478671_m1, Applied Biosystems, Foster City, CA) and the housekeeping gene glyceraldehyde-3-phosphate dehydrogenase (GAPDH, Mm99999915_g1, Applied Biosystems).
Localization (utilized) of BACE1 mRNA
8) Confidence 0.75 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0 Pain Relevance 0
Murayama and colleagues reported the release of detectable levels of BACE1 holoprotein in vitro [101], although the physiological relevance of this event remains to be clarified.
Localization (release) of BACE1
9) Confidence 0.74 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
While further studies are required, the co-localization of BACE1 immunoreactivity with synaptophysin, but not MAP2, suggested a presynaptic localization for BACE1.
Localization (localization) of BACE1
10) Confidence 0.74 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.56 Pain Relevance 0
-secretase is located within the lumen of acidic intracellular compartments.
Localization (located) of secretase in lumen
11) Confidence 0.74 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
This trafficking pattern is consistent with observations in vivo indicating that BACE1 is transported down axons of the perforant pathway [98] and that axon terminals may be major sites of A?
Localization (transported) of BACE1
12) Confidence 0.74 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
subunits are BACE1 substrates, and BACE1 cleavage generates a membrane-bound ?
Localization (cleavage) of BACE1 in cleavage
13) Confidence 0.74 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.07 Pain Relevance 0.23
Overall these early findings indicated that the absence of BACE1 is well tolerated in vivo and does not appear to cause untoward effects in the developing, post-natal, or adult mouse.
Neg (absence) Localization (absence) of BACE1 in adult mouse
14) Confidence 0.74 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.24 Pain Relevance 0
While further studies are required, the co-localization of BACE1 immunoreactivity with synaptophysin, but not MAP2, suggested a presynaptic localization for BACE1.
Localization (localization) of BACE1
15) Confidence 0.74 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.54 Pain Relevance 0
Importantly, data generated from BACE1 null mice showed that the absence of BACE1 was associated with hypomyelination of both CNS and PNS axons.
Neg (absence) Localization (absence) of BACE1 in PNS associated with peripheral nervous system and central nervous system
16) Confidence 0.74 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.08 Pain Relevance 0.30
The authors propose that these data indicate that normal brain functions are facilitated by the regulated, activity-dependent cleavage of APP by BACE1 in neurons.
Localization (cleavage) of BACE1 in neurons
17) Confidence 0.74 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.30 Pain Relevance 0
and AD, and the elevation of BACE1 in this disease, this enzyme is a prime drug target for inhibiting A?
Localization (elevation) of BACE1 associated with disease
18) Confidence 0.74 Published 2007 Journal Current Genomics Section Abstract Doc Link PMC2647160 Disease Relevance 1.41 Pain Relevance 0
While further studies are required, the co-localization of BACE1 immunoreactivity with synaptophysin, but not MAP2, suggested a presynaptic localization for BACE1.
Localization (localization) of BACE1
19) Confidence 0.74 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.79 Pain Relevance 0
The intracellular trafficking and localization of the BACE1 protein is largely controlled by targeting signals present in the cytosolic portion of the C-terminal tail [127].
Localization (localization) of BACE1 protein in tail
20) Confidence 0.74 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.07 Pain Relevance 0

General Comments

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