INT220599

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.66
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
cleavage 8
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 12 80.12 Quite High
Inflammation 62 48.76 Quite Low
cytokine 20 38.40 Quite Low
Central nervous system 32 32.84 Quite Low
antagonist 10 16.60 Low Low
agonist 12 12.16 Low Low
ischemia 34 5.00 Very Low Very Low Very Low
Peripheral nervous system 28 5.00 Very Low Very Low Very Low
cINOD 24 5.00 Very Low Very Low Very Low
sodium channel 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 72 90.48 High High
Disease 640 89.84 High High
INFLAMMATION 78 79.76 Quite High
Adhesions 6 48.12 Quite Low
Cardiovascular Disease 18 32.84 Quite Low
Drug Induced Neurotoxicity 6 32.08 Quite Low
Hypercholesterolemia 18 30.00 Quite Low
Targeted Disruption 192 5.00 Very Low Very Low Very Low
Stress 166 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 146 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
Positive_regulation (-) of BACE1 Binding (interaction) of
1) Confidence 0.50 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.08 Pain Relevance 0
Cleavage of IL-1R2 by both BACE enzymes occurred at sites that agreed well with the known cleavage specificity of BACE1 and BACE2 and led to the generation of CTF that were similar to those generated by ?
Positive_regulation (cleavage) of BACE1 Binding (specificity) of in cleavage
2) Confidence 0.50 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.17 Pain Relevance 0.04
Cleavage of IL-1R2 by both BACE enzymes occurred at sites that agreed well with the known cleavage specificity of BACE1 and BACE2 and led to the generation of CTF that were similar to those generated by ?
Positive_regulation (agreed) of BACE1 Binding (specificity) of in cleavage
3) Confidence 0.50 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.17 Pain Relevance 0.04
-secretase complex are essential for A?
Positive_regulation (essential) of secretase Binding (complex) of
4) Confidence 0.50 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.09 Pain Relevance 0
Cleavage of IL-1R2 by both BACE enzymes occurred at sites that agreed well with the known cleavage specificity of BACE1 and BACE2 and led to the generation of CTF that were similar to those generated by ?
Positive_regulation (cleavage) of BACE1 Binding (specificity) of in cleavage
5) Confidence 0.49 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.08 Pain Relevance 0.04
Cleavage of IL-1R2 by both BACE enzymes occurred at sites that agreed well with the known cleavage specificity of BACE1 and BACE2 and led to the generation of CTF that were similar to those generated by ?
Positive_regulation (agreed) of BACE1 Binding (specificity) of in cleavage
6) Confidence 0.49 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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