INT220600

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
neurons 1
astrocytes 1
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 99.70 Very High Very High Very High
glial activation 2 97.20 Very High Very High Very High
Inflammatory response 3 95.36 Very High Very High Very High
agonist 4 92.36 High High
cINOD 56 90.64 High High
cytokine 10 37.52 Quite Low
COX-2 inhibitor 1 29.28 Quite Low
Central nervous system 6 22.04 Low Low
ischemia 7 11.52 Low Low
Peripheral nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 34 99.70 Very High Very High Very High
Amyloid Plaque 12 95.96 Very High Very High Very High
Targeted Disruption 37 95.04 Very High Very High Very High
Disease 48 80.24 Quite High
Cognitive Disorder 28 72.28 Quite High
Necrosis 2 39.28 Quite Low
Cancer 2 38.92 Quite Low
Stress 31 22.96 Low Low
Brain Injury 9 14.88 Low Low
Hypoxia 18 12.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
levels under inflammatory conditions by affecting BACE1 transcription (Sastre et al., 2006b, 2008).
Regulation (affecting) of Transcription (transcription) of BACE1 associated with inflammation
1) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 0.63 Pain Relevance 0.62
While it is apparent that BACE1 expression can be tightly regulated at the transcriptional level, in some studies BACE1 mRNA levels in either neurons or astrocytes around amyloid plaques in APP transgenic brain are not elevated [97,100,101], implying that a post-translational mechanism may be responsible for the BACE1 increase.
Regulation (regulated) of in neurons Transcription (at) of BACE1 in astrocytes associated with targeted disruption and amyloid plaque
2) Confidence 0.27 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.32 Pain Relevance 0.19

General Comments

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