INT220601

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.38
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fancd2) cell cycle (Fancd2)
Fancd2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 14 70.28 Quite High
positron emission tomography 4 69.96 Quite High
palliative 4 29.16 Quite Low
Inflammation 36 5.00 Very Low Very Low Very Low
ischemia 28 5.00 Very Low Very Low Very Low
cINOD 26 5.00 Very Low Very Low Very Low
Central nervous system 24 5.00 Very Low Very Low Very Low
Peripheral nervous system 24 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
sodium channel 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 66 100.00 Very High Very High Very High
Syndrome 68 85.92 High High
Targeted Disruption 137 84.24 Quite High
Cognitive Disorder 84 75.60 Quite High
Alzheimer's Dementia 127 71.00 Quite High
Amyloid Plaque 40 69.36 Quite High
Death 29 64.80 Quite High
Stress 124 53.88 Quite High
Heart Disease 8 52.96 Quite High
Stroke 20 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substitutions of larger hydrophobic amino acids (such as Leu found in the Swedish FAD mutation) for the Met residue at P1 improve the efficiency of ?
Gene_expression (mutation) of FAD
1) Confidence 0.04 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.07 Pain Relevance 0
42 overproduction with FAD argues strongly in favor of a critical role for A?
Gene_expression (overproduction) of FAD
2) Confidence 0.04 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.96 Pain Relevance 0
The model also showed that the Swedish FAD mutation, LysMet?
Gene_expression (mutation) of FAD
3) Confidence 0.04 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0 Pain Relevance 0
Given the strong genetic evidence from FAD cases, we maintain that A?
Gene_expression (cases) of FAD
4) Confidence 0.04 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.25 Pain Relevance 0.07
We observed a small but statistically significant increase in the average 598/513 ratio distribution in cells expressing the FAD mutant PS1 (Figure 2B).
Gene_expression (expressing) of FAD associated with disease
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.10 Pain Relevance 0

General Comments

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