INT220609

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.60
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
cleavage 2
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 5 88.16 High High
sodium channel 13 83.92 Quite High
Nav1.1 11 74.24 Quite High
ischemia 29 72.96 Quite High
Peripheral nervous system 24 26.68 Quite Low
Central nervous system 27 26.36 Quite Low
Inflammation 51 5.00 Very Low Very Low Very Low
cINOD 21 5.00 Very Low Very Low Very Low
Hippocampus 18 5.00 Very Low Very Low Very Low
cytokine 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 61 98.60 Very High Very High Very High
Disease 522 95.44 Very High Very High Very High
Targeted Disruption 182 89.68 High High
Stress 140 88.24 High High
Hypoxia 78 87.36 High High
Cv Unclassified Under Development 24 72.96 Quite High
Contagious Ecthyma 6 58.12 Quite High
Death 39 51.52 Quite High
Injury 26 33.20 Quite Low
Cognitive Disorder 86 33.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the ablation of a single BACE1 allele is not sufficient to prevent BACE1-elevating mechanisms, thus maintaining wild-type levels of this enzyme (i.e., twice the gene copy number) in BACE1+/?
Positive_regulation (single) of Localization (allele) of BACE1
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.16 Pain Relevance 0
subunits are BACE1 substrates, and BACE1 cleavage generates a membrane-bound ?
Positive_regulation (generates) of Localization (cleavage) of BACE1 in cleavage
2) Confidence 0.50 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.07 Pain Relevance 0.23
Thus, Tesco and colleagues suggested that apoptosis, caused by ischemic events, drives GGA3 depletion and results in the stabilization and accumulation of BACE1 leading to elevated enzymatic activity.
Positive_regulation (accumulation) of Localization (stabilization) of BACE1 associated with apoptosis
3) Confidence 0.43 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.80 Pain Relevance 0.04
The mechanism of the energy-induced BACE1 increase in vivo is unclear and will likely be challenging to elucidate.
Positive_regulation (induced) of Localization (increase) of BACE1
4) Confidence 0.43 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.54 Pain Relevance 0
Thus, Tesco and colleagues suggested that apoptosis, caused by ischemic events, drives GGA3 depletion and results in the stabilization and accumulation of BACE1 leading to elevated enzymatic activity.
Positive_regulation (accumulation) of Localization (stabilization) of BACE1 associated with apoptosis
5) Confidence 0.43 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.59 Pain Relevance 0.04
The mechanism of the energy-induced BACE1 increase in vivo is unclear and will likely be challenging to elucidate.
Positive_regulation (induced) of Localization (increase) of BACE1
6) Confidence 0.43 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.44 Pain Relevance 0

General Comments

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