INT220611

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.47
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace2) peptidase activity (Bace2) Golgi apparatus (Bace2)
endoplasmic reticulum (Bace2)
Anatomy Link Frequency
cleavage 2
Bace2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 6 78.68 Quite High
antagonist 5 78.40 Quite High
Thalamus 2 74.08 Quite High
Inflammation 31 47.32 Quite Low
cytokine 10 36.96 Quite Low
Central nervous system 16 31.40 Quite Low
ischemia 17 5.00 Very Low Very Low Very Low
Peripheral nervous system 14 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
sodium channel 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 351 91.04 High High
Increased Venous Pressure Under Development 29 89.40 High High
Cardiovascular Disease 52 79.44 Quite High
Syndrome 47 78.68 Quite High
INFLAMMATION 39 78.32 Quite High
Targeted Disruption 96 70.56 Quite High
Adhesions 3 46.68 Quite Low
Alzheimer's Dementia 73 36.92 Quite Low
Cognitive Disorder 47 36.08 Quite Low
Drug Induced Neurotoxicity 3 30.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cleavage of IL-1R2 by both BACE enzymes occurred at sites that agreed well with the known cleavage specificity of BACE1 and BACE2 and led to the generation of CTF that were similar to those generated by ?
BACE2 Binding (specificity) of in cleavage
1) Confidence 0.29 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.08 Pain Relevance 0.04
Cleavage of IL-1R2 by both BACE enzymes occurred at sites that agreed well with the known cleavage specificity of BACE1 and BACE2 and led to the generation of CTF that were similar to those generated by ?
BACE2 Binding (specificity) of in cleavage
2) Confidence 0.28 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.17 Pain Relevance 0.04
In vitro, BACE2 can cleave APP at the ?
BACE2 Binding (In vitro) of
3) Confidence 0.25 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.15 Pain Relevance 0.08
These results corroborate an earlier multicenter study by Carpentier (2004), which also revealed a statistically significant association between a higher CEAP grade and an older current age of patients.
CEAP Binding (association) of
4) Confidence 0.01 Published 2010 Journal Hum Genet Section Body Doc Link PMC2871097 Disease Relevance 1.08 Pain Relevance 0

General Comments

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