INT220614

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 5.32
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
brain 9
plaques 1
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 38 90.52 High High
glial activation 6 86.48 High High
Inflammation 58 84.48 Quite High
agonist 12 81.64 Quite High
cINOD 30 79.92 Quite High
Hippocampus 63 74.16 Quite High
cytokine 22 58.76 Quite High
Central nervous system 34 11.32 Low Low
Peripheral nervous system 32 5.00 Very Low Very Low Very Low
sodium channel 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 523 99.84 Very High Very High Very High
Brain Injury 46 99.76 Very High Very High Very High
Apoptosis 78 99.62 Very High Very High Very High
Targeted Disruption 274 98.20 Very High Very High Very High
Amyloid Plaque 65 97.84 Very High Very High Very High
Disease Progression 24 97.28 Very High Very High Very High
Stroke 24 94.40 High High
Stress 241 93.08 High High
Injury 36 92.80 High High
Cv Unclassified Under Development 32 90.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paradoxically, in some studies BACE1 mRNA levels in either neurons or astrocytes around amyloid plaques in APP transgenic brain are not elevated [69, 143, 199], implying that a post-transcriptional mechanism may be responsible for the BACE1 increase.
Spec (may) Regulation (responsible) of Positive_regulation (increase) of BACE1 in brain associated with targeted disruption and amyloid plaque
1) Confidence 0.45 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.02 Pain Relevance 0.33
Data derived from a rat model of TBI supports a role for BACE1 elevation in the increase of A?
Regulation (role) of Positive_regulation (elevation) of BACE1 associated with brain injury
2) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 1.31 Pain Relevance 0.15
While it is apparent that BACE1 expression can be tightly regulated at the transcriptional level, in some studies BACE1 mRNA levels in either neurons or astrocytes around amyloid plaques in APP transgenic brain are not elevated [97,100,101], implying that a post-translational mechanism may be responsible for the BACE1 increase.
Spec (may) Regulation (responsible) of in plaques Positive_regulation (increase) of BACE1 in brain associated with targeted disruption and amyloid plaque
3) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.31 Pain Relevance 0.16
underlies the age-dependent increase in BACE1 in 5XFAD mice and that the persistent upregulation of BACE1 through the greater phosphorylation of eIF2?
Regulation (underlies) of Positive_regulation (increase) of BACE1
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.08 Pain Relevance 0
underlies the age-dependent increase in BACE1 in 5XFAD mice and that the persistent upregulation of BACE1 through the greater phosphorylation of eIF2?
Regulation (dependent) of Positive_regulation (increase) of BACE1
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.08 Pain Relevance 0
underlies the age-dependent increase in BACE1 in 5XFAD mice and that the persistent upregulation of BACE1 through the greater phosphorylation of eIF2?
Regulation (underlies) of Positive_regulation (upregulation) of BACE1
6) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.09 Pain Relevance 0
While other post-translational mechanisms may account for this observed decrease in GGA3, it is tempting to speculate that apoptotic events may play a role in the increase in BACE1 in AD brain, indeed, elevated BACE1 activity may lead to increased A?
Spec (may) Regulation (role) of Positive_regulation (increase) of BACE1 in brain associated with disease and apoptosis
7) Confidence 0.39 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.80 Pain Relevance 0.03
Indeed, whether the BACE1 elevation in AD promotes A?
Spec (whether) Regulation (whether) of Spec (whether) Positive_regulation (elevation) of BACE1
8) Confidence 0.39 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.45 Pain Relevance 0
While other post-translational mechanisms may account for this observed decrease in GGA3, it is tempting to speculate that apoptotic events may play a role in the increase in BACE1 in AD brain, Indeed, elevated BACE1 activity may lead to increased A?
Spec (may) Regulation (role) of Positive_regulation (increase) of BACE1 in brain associated with apoptosis
9) Confidence 0.39 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.52 Pain Relevance 0.03
Some studies with postmortem human brains report elevations in BACE1 mRNA levels associated with sporadic AD [21,51], while others show no changes in mRNA despite the increased levels of BACE1 activity and protein [22,52-54].
Neg (no) Regulation (changes) of Positive_regulation (increased) of BACE1 in brains associated with disease
10) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.67 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox