INT220615

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.65
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 99.98 Very High Very High Very High
cINOD 12 99.20 Very High Very High Very High
cytokine 8 98.32 Very High Very High Very High
Inflammation 19 89.36 High High
Neuronal excitability 3 75.32 Quite High
potassium channel 2 73.00 Quite High
sodium channel 8 62.72 Quite High
Pain 1 52.60 Quite High
Central nervous system 12 26.16 Quite Low
antagonist 2 10.28 Low Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Alzheimer's Dementia 63 99.96 Very High Very High Very High
Targeted Disruption 77 99.42 Very High Very High Very High
INFLAMMATION 27 98.64 Very High Very High Very High
Disease 66 97.44 Very High Very High Very High
Cognitive Disorder 45 94.72 High High
Stress 63 83.88 Quite High
Syndrome 39 75.20 Quite High
Pain 1 52.60 Quite High
Death 17 52.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
agonists cause repression of BACE1 gene promoter activity, while proinflammatory cytokines that reduce PPAR?
Positive_regulation (cause) of Negative_regulation (repression) of BACE1 gene associated with repression, agonist and cytokine
1) Confidence 0.49 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.60 Pain Relevance 0.63
While BACE2 knockout mice are healthy overall, a deficiency of both BACE1 and BACE2 enhanced the BACE1 KO lethality phenotype, suggesting a slight functional redundancy [84].
Positive_regulation (enhanced) of Negative_regulation (deficiency) of BACE1 associated with targeted disruption
2) Confidence 0.48 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.53 Pain Relevance 0.08
Interestingly, Singer and colleagues used RNA interference (RNAi) to silence BACE1 and demonstrated that a partial reduction in BACE1 can improve amyloid neuropathology including the deposition of A?
Positive_regulation (improve) of Spec (partial) Negative_regulation (reduction) of BACE1 associated with alzheimer's dementia
3) Confidence 0.43 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.52 Pain Relevance 0.07

General Comments

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