INT220623

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 10.33
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Stat1, Bace1) endosome (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
astrocytes 1
Stat1 (Mus musculus)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 342 96.04 Very High Very High Very High
Inflammation 382 89.60 High High
cytokine 98 83.96 Quite High
Hippocampus 43 67.92 Quite High
Central nervous system 33 67.64 Quite High
agonist 26 64.24 Quite High
glial activation 20 21.20 Low Low
ischemia 36 5.00 Very Low Very Low Very Low
antagonist 30 5.00 Very Low Very Low Very Low
Peripheral nervous system 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 7 98.80 Very High Very High Very High
Amyloid Plaque 137 91.36 High High
INFLAMMATION 463 89.60 High High
Targeted Disruption 314 88.48 High High
Necrosis 23 84.88 Quite High
Stress 192 84.80 Quite High
Cancer 23 84.52 Quite High
Alzheimer's Dementia 202 83.92 Quite High
Disease 865 81.20 Quite High
Gliosis 7 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following phosphorylation, STAT-1 then binds to the putative STAT1 binding sequence in the BACE1 promoter region to modulate astrocytic BACE1 expression [92].
STAT-1 Binding (binds) of BACE1
1) Confidence 0.25 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.54 Pain Relevance 0.17
Following phosphorylation, STAT-1 then binds to the putative STAT1 binding sequence in the BACE1 promoter region to modulate astrocytic BACE1 expression [92].
STAT-1 Binding (binds) of BACE1
2) Confidence 0.25 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.54 Pain Relevance 0.17
Following phosphorylation, STAT-1 then binds to the putative STAT1 binding sequence in the BACE1 promoter region to modulate astrocytic BACE1 expression [92].
STAT1 Binding (binds) of BACE1
3) Confidence 0.25 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.53 Pain Relevance 0.17
Following phosphorylation, STAT-1 then binds to the putative STAT1 binding sequence in the BACE1 promoter region to modulate astrocytic BACE1 expression [192].
STAT-1 Binding (binds) of BACE1
4) Confidence 0.24 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.10 Pain Relevance 0.14
Following phosphorylation, STAT-1 then binds to the putative STAT1 binding sequence in the BACE1 promoter region to modulate astrocytic BACE1 expression [192].
STAT1 Binding (binds) of BACE1
5) Confidence 0.24 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.04 Pain Relevance 0.11
Following phosphorylation, STAT-1 then binds to the putative STAT1 binding sequence in the BACE1 promoter region to modulate astrocytic BACE1 expression [192].
STAT-1 Binding (binds) of BACE1
6) Confidence 0.24 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.10 Pain Relevance 0.14
-mediated activation of JAK2 and ERK1/2, STAT1 binds to BACE1 promoter region to increase BACE1 protein expression in astrocytes [91].
STAT1 Binding (binds) of BACE1 in astrocytes
7) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.77 Pain Relevance 0.39
STAT-1 can bind directly to a putative STAT1 binding sequence in the BACE1 promoter.
STAT1 Binding (bind) of BACE1
8) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.79 Pain Relevance 0.42
STAT-1 can bind directly to a putative STAT1 binding sequence in the BACE1 promoter.
STAT1 Binding (bind) of BACE1
9) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.79 Pain Relevance 0.42
STAT-1 can bind directly to a putative STAT1 binding sequence in the BACE1 promoter.
STAT-1 Binding (bind) of BACE1
10) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.79 Pain Relevance 0.42
STAT-1 can bind directly to a putative STAT1 binding sequence in the BACE1 promoter.
STAT1 Binding (binding) of BACE1
11) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.78 Pain Relevance 0.41
STAT-1 can bind directly to a putative STAT1 binding sequence in the BACE1 promoter.
STAT1 Binding (binding) of BACE1
12) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.78 Pain Relevance 0.41
STAT-1 can bind directly to a putative STAT1 binding sequence in the BACE1 promoter.
STAT-1 Binding (bind) of BACE1
13) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.79 Pain Relevance 0.42

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