INT220630

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1, Gga1) Golgi apparatus (Bace1, Gga1) transport (Gga1)
endoplasmic reticulum (Bace1) intracellular (Gga1) enzyme binding (Bace1)
Bace1 (Mus musculus)
Gga1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 3 27.68 Quite Low
Inflammation 51 5.00 Very Low Very Low Very Low
ischemia 29 5.00 Very Low Very Low Very Low
Central nervous system 27 5.00 Very Low Very Low Very Low
Peripheral nervous system 24 5.00 Very Low Very Low Very Low
cINOD 21 5.00 Very Low Very Low Very Low
cytokine 17 5.00 Very Low Very Low Very Low
sodium channel 12 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Nav1.1 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 61 66.80 Quite High
Disease 487 50.00 Quite Low
Neuroblastoma 3 33.68 Quite Low
Aging 21 18.96 Low Low
Targeted Disruption 161 5.00 Very Low Very Low Very Low
Stress 140 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 124 5.00 Very Low Very Low Very Low
Cognitive Disorder 81 5.00 Very Low Very Low Very Low
Syndrome 79 5.00 Very Low Very Low Very Low
Hypoxia 78 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus not only does GGA1 interact with BACE1, but it acts also as a sorting protein that affects APP trafficking and ultimately the proteolysis of this molecule.
BACE1 Binding (interact) of GGA1
1) Confidence 0.25 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.07 Pain Relevance 0
Thus not only does GGA1 interact with BACE1, but it acts also as a sorting protein that affects APP trafficking and ultimately the proteolysis of this molecule [243, 244].
BACE1 Binding (interact) of GGA1
2) Confidence 0.24 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
GGA1 interacts with BACE1 and influences BACE1 trafficking through the recycling pathway.
BACE1 Binding (interacts) of GGA1
3) Confidence 0.21 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
GGA1 interacts with BACE1 and influences BACE1 trafficking through the recycling pathway.
BACE1 Binding (trafficking) of GGA1
4) Confidence 0.16 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
GGA1 interacts with BACE1 and influences BACE1 trafficking through the secretory pathway.
BACE1 Binding (interacts) of GGA1
5) Confidence 0.16 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0 Pain Relevance 0

General Comments

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