INT220634

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Bace1, Pawr) endosome (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) cytoplasm (Pawr) peptidase activity (Bace1)
Anatomy Link Frequency
brain 2
Bace1 (Mus musculus)
Pawr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 6.24 Low Low
Inflammation 20 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
Central nervous system 11 5.00 Very Low Very Low Very Low
Peripheral nervous system 10 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 25 100.00 Very High Very High Very High
Disease 167 50.00 Quite Low
Cardiovascular Disease 5 22.48 Low Low
Hypercholesterolemia 6 19.64 Low Low
Targeted Disruption 65 5.00 Very Low Very Low Very Low
Stress 57 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 51 5.00 Very Low Very Low Very Low
Cognitive Disorder 34 5.00 Very Low Very Low Very Low
Hypoxia 32 5.00 Very Low Very Low Very Low
Syndrome 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, a variety of molecules have been shown to interact with BACE1 and increase enzyme activity, like prostate apoptosis response-4 (PAR-4) protein [119], while the effects of other interacting partners, such as the copper chaperone for superoxide dismutase-1 [120] and the brain-specific Type II membrane protein BRI3 [121], remain unclear.
BACE1 Binding (interact) of PAR-4 in brain associated with apoptosis
1) Confidence 0.06 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.10 Pain Relevance 0
Other molecules have been shown to interact with BACE1 and increase enzyme activity, like prostate apoptosis response-4 (PAR-4) protein [227], while the effects of other interacting partners, such as the copper chaperone for superoxide dismutase-1 [228] and the brain-specific Type II membrane protein BRI3 [229], remain unclear.
BACE1 Binding (interact) of PAR-4 in brain associated with apoptosis
2) Confidence 0.06 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.10 Pain Relevance 0

General Comments

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