INT220635

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Lrp1, Kat5) nucleus (Lrp1, Kat5) endosome (Lrp1)
transferase activity, transferring acyl groups (Kat5) protein complex (Kat5) cell proliferation (Lrp1)
Anatomy Link Frequency
nucleus 2
Lrp1 (Mus musculus)
Kat5 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 11 67.20 Quite High
Inflammation 20 66.88 Quite High
cytokine 7 56.56 Quite High
Inflammatory response 4 43.92 Quite Low
ischemia 12 5.00 Very Low Very Low Very Low
Peripheral nervous system 10 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Nav1.1 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 167 72.80 Quite High
Drug Induced Neurotoxicity 2 69.52 Quite High
INFLAMMATION 26 66.88 Quite High
Toxicity 4 65.96 Quite High
Alzheimer's Dementia 51 60.00 Quite High
Adhesions 2 37.04 Quite Low
Hypercholesterolemia 6 34.56 Quite Low
Targeted Disruption 65 5.00 Very Low Very Low Very Low
Stress 57 5.00 Very Low Very Low Very Low
Cognitive Disorder 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LRP-ICD has been shown to translocate to the nucleus and interact with Fe65 and Tip60, although whether this occurs under physiological conditions remains to be determined.
LRP Binding (interact) of Tip60 in nucleus
1) Confidence 0.09 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.39 Pain Relevance 0.12
The LRP-ICD has been shown to translocate to the nucleus and interact with Fe65 and Tip60, although whether this occurs under physiological conditions remains to be determined.
LRP Binding (interact) of Tip60 in nucleus
2) Confidence 0.04 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.32 Pain Relevance 0.12

General Comments

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