INT220636

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Lrp1, Bace1) cell proliferation (Lrp1) peptidase activity (Bace1)
Golgi apparatus (Bace1) endoplasmic reticulum (Bace1) plasma membrane (Lrp1)
Anatomy Link Frequency
brain 2
Lrp1 (Mus musculus)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 11 24.08 Low Low
Inflammation 20 23.76 Low Low
cytokine 7 13.44 Low Low
ischemia 12 5.00 Very Low Very Low Very Low
Peripheral nervous system 10 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Nav1.1 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 4 84.88 Quite High
Alzheimer's Dementia 51 78.92 Quite High
Disease 167 68.80 Quite High
Hypercholesterolemia 6 53.76 Quite High
Drug Induced Neurotoxicity 2 26.40 Quite Low
INFLAMMATION 26 23.76 Low Low
Targeted Disruption 65 5.00 Very Low Very Low Very Low
Stress 57 5.00 Very Low Very Low Very Low
Cognitive Disorder 34 5.00 Very Low Very Low Very Low
Hypoxia 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous BACE1 and LRP co-immunoprecipitate from human brain and it appears as if the LRP-BACE1 complexes occur in lipid-rafts, with the closest association being at the cell surface.
LRP Binding (complexes) of BACE1 in brain
1) Confidence 0.32 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.41 Pain Relevance 0
Endogenous BACE1 and LRP co-immunoprecipitate from human brain and it appears as if the LRP-BACE1 complexes occur in lipid-rafts, with the closest association being at the cell surface.
LRP Binding (complexes) of BACE1 in brain
2) Confidence 0.17 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.22 Pain Relevance 0

General Comments

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