INT22066

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 40
Total Number 47
Disease Relevance 22.51
Pain Relevance 25.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Anatomy Link Frequency
sciatic nerve 4
neurons 3
nerve 3
spinal cord 2
bladders 1
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 635 100.00 Very High Very High Very High
c fibre 493 100.00 Very High Very High Very High
Spinal cord 461 100.00 Very High Very High Very High
agonist 168 100.00 Very High Very High Very High
analgesia 165 100.00 Very High Very High Very High
Sciatic nerve 153 100.00 Very High Very High Very High
Hyperalgesia 116 100.00 Very High Very High Very High
intrathecal 239 99.98 Very High Very High Very High
antinociception 1 99.98 Very High Very High Very High
nociceptor 50 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 447 100.00 Very High Very High Very High
Hyperalgesia 151 100.00 Very High Very High Very High
Ganglion Cysts 377 99.36 Very High Very High Very High
Neuropathic Pain 277 99.36 Very High Very High Very High
Hypoalagesia 20 99.36 Very High Very High Very High
Spinal Cord Injury 19 99.24 Very High Very High Very High
Nervous System Injury 580 99.16 Very High Very High Very High
Interstitial Cystitis 3 99.16 Very High Very High Very High
Hypersensitivity 139 99.00 Very High Very High Very High
Pain 366 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RBP-26 is expressed in non-neuronal and capsaicin-insensitive neuronal tissues, and shows distinct binding characteristics from the resiniferatoxin binding site defined on DRG membranes.
Gene_expression (expressed) of RBP-26 in neuronal associated with qutenza
1) Confidence 0.78 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8015392 Disease Relevance 0.05 Pain Relevance 0.27
It is reported here that RTX, like capsaicin, acts selectively on primary sensory neurons in rats to produce ultrastructural alterations and calcitonin gene-related peptide depletion.
Gene_expression (produce) of RTX in primary sensory neurons associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.62 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2243359 Disease Relevance 0.21 Pain Relevance 0.63
RESULTS: A single application of RTX produced nociceptive-selective sciatic nerve block, whereas antidepressants produced nociceptive and motor block.
Gene_expression (produced) of RTX in sciatic nerve
3) Confidence 0.59 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20519419 Disease Relevance 0 Pain Relevance 0
RTX treatment resulted in a significant and long-lasting (i.e. essentially irreversible) decrease in sensitivity to thermal noxious stimuli in both sham-operated and nerve-injured rats; thermal hyperalgesia was abolished and antinociception produced by RTX.
Gene_expression (produced) of RTX in nerve associated with antinociception and thermal hyperalgesia
4) Confidence 0.59 Published 1999 Journal Pain Section Abstract Doc Link 10068158 Disease Relevance 1.12 Pain Relevance 1.52
Patients with interstitial cystitis (IC) failed to benefit from this treatment, but a single placebo-controlled study in patients with non-IC painful bladders showed that RTX was effective in the short-term.
Gene_expression (effective) of RTX in bladders associated with pain and interstitial cystitis
5) Confidence 0.57 Published 2006 Journal Eur. Urol. Section Abstract Doc Link 16697519 Disease Relevance 0.46 Pain Relevance 0.39
Both expressed bacterial fusion proteins and cytoplasmic fractions from COS cells transfected with an expression vector encoding RTX-42 showed [3H]resiniferatoxin binding activity (IC50 approximately 10 nM).
Gene_expression (expression) of RTX-42
6) Confidence 0.53 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8015392 Disease Relevance 0.06 Pain Relevance 0.27
Recently, it has been demonstrated that intrathecal delivery of resiniferatoxin (RTX) produces strong analgesia, even in models of bone cancer pain.
Gene_expression (produces) of resiniferatoxin associated with cancer pain, bone cancer, analgesia and intrathecal
7) Confidence 0.46 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18824169 Disease Relevance 0.67 Pain Relevance 0.42
Recently, it has been demonstrated that intrathecal delivery of resiniferatoxin (RTX) produces strong analgesia, even in models of bone cancer pain.
Gene_expression (produces) of RTX associated with cancer pain, bone cancer, analgesia and intrathecal
8) Confidence 0.46 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18824169 Disease Relevance 0.67 Pain Relevance 0.42
Levels of phosphorylated-p38 were decreased in SCI animals receiving minocycline.
Gene_expression (Levels) of phosphorylated-p38 associated with spinal cord injury
9) Confidence 0.24 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16624951 Disease Relevance 1.56 Pain Relevance 0.87
Thus, RTX produced marked and prolonged impairment of capsaicin-sensitive afferents and upregulation of the inhibitory neuropeptides GMAP and galanin in DRG neurons, which may underlie the prolonged effect of RTX.
Gene_expression (produced) of RTX in neurons associated with dorsal root ganglion, qutenza and neuropeptide
10) Confidence 0.22 Published 1997 Journal Brain Res. Section Abstract Doc Link 9106440 Disease Relevance 0.53 Pain Relevance 0.89
RTX, but not vehicle, produced marked thermal hypoalgesia on the hot plate test with partial recovery in about 50% of animals after about 2 weeks and no recovery in the remaining rats after 4 weeks.
Gene_expression (produced) of RTX associated with hypoalgesia
11) Confidence 0.22 Published 1997 Journal Brain Res. Section Abstract Doc Link 9106440 Disease Relevance 0.45 Pain Relevance 0.63
behavioral responses after RTX may indicate that the A?
Gene_expression (responses) of RTX
12) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.05 Pain Relevance 0.61
After RTX injection, the probability of withdrawal and the severity of withdrawal were eliminated or barely detectable during the first two weeks.
Gene_expression (injection) of RTX associated with withdrawal
13) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0 Pain Relevance 0.25
and C stimuli on day 18; after 50 ng RTX, rats were generally unresponsive to the 5.12 W/mm2 A?
Gene_expression (unresponsive) of RTX
14) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0 Pain Relevance 0.51
After 50 ng RTX, rats were almost completely unresponsive to the 6.08 W/mm2 A?
Gene_expression (unresponsive) of RTX
15) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0 Pain Relevance 0.32
In contrast, ATF3, a marker of nerve regeneration [37,53], exhibited an increase at 24 h that was sustained at both day 5 and 10, indicative of a long-lasting regenerative process after intraplantar injection of RTX.
Gene_expression (injection) of RTX in nerve
16) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.65 Pain Relevance 0.51
Therapeutically, prolonged behavioral recovery at sites distal to an RTX injection indicates that regional analgesia can be sustained longer by injecting RTX more proximal to the DRG and has potential therapeutic ramifications for treatment of peripheral neuropathic pain problems subsequent to nerve injury or possibly chemotherapy.
Gene_expression (injection) of RTX in nerve associated with nervous system injury, neuropathic pain and analgesia
17) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.18 Pain Relevance 0.37
Ablation of TRPV1-expressing nociceptive fibers with the potent capsaicin analog resiniferatoxin (RTX) results in long lasting pain relief.
Gene_expression (expressing) of RTX associated with pain, nociception, qutenza and lasting pain
18) Confidence 0.17 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3019206 Disease Relevance 0.25 Pain Relevance 0.51
Using RT-PCR, we examined the DRG and spinal cord for expression of genes associated with nociceptive activity and nerve regeneration after RTX-treatment.
Spec (examined) Gene_expression (expression) of RTX in spinal cord associated with nociception and spinal cord
19) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.42 Pain Relevance 0.31
PURPOSE: Resiniferatoxin (RTX) is a specific C fiber neurotoxin which produces desensitization.
Gene_expression (produces) of Resiniferatoxin associated with c fibre
20) Confidence 0.15 Published 2004 Journal J. Urol. Section Abstract Doc Link 15247740 Disease Relevance 0.17 Pain Relevance 0.10

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