INT220662

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.17
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Camk1) signal transduction (Camk1) nucleocytoplasmic transport (Camk1)
nucleus (Camk1) cell cycle (Camk1) kinase activity (Camk1)
Anatomy Link Frequency
brain 1
T-lymphocytes 1
Camk1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 18 96.12 Very High Very High Very High
Inflammatory response 12 90.96 High High
Hippocampus 6 80.64 Quite High
amygdala 3 79.60 Quite High
Anterior cingulate cortex 3 78.80 Quite High
Somatosensory cortex 3 76.64 Quite High
Inflammation 32 72.12 Quite High
Eae 45 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 262 100.00 Very High Very High Very High
Anxiety Disorder 186 97.96 Very High Very High Very High
Schizophrenia 9 96.68 Very High Very High Very High
Cv General 4 Under Development 18 96.12 Very High Very High Very High
Adult Respiratory Distress Syndrome 84 94.64 High High
Lung Injury 14 92.80 High High
INFLAMMATION 44 90.56 High High
Injury 12 74.40 Quite High
Sepsis 10 69.56 Quite High
Sprains And Strains 23 68.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to the ubiquitous expression of CaMKI, the tissue distribution pattern of CaMKIV is rather limited, with expression restricted primarily to discrete regions of the brain, T-lymphocytes, and post-meiotic germ cells [20], [21], [22], [23].
Gene_expression (expression) of CaMKI in T-lymphocytes
1) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.17 Pain Relevance 0.16
Together, our results suggest that CaMKI deficiency does not cause abnormal behavior related to neuropsychiatric disorders, including schizophrenia, and also suggest that CaMKIV is dispensable for fear memory in contrast to the generally believed role of CaMKIV in learning and memory.


Gene_expression (deficiency) of CaMKI associated with anxiety disorder and schizophrenia
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.74 Pain Relevance 0
Compared to the ubiquitous expression of CaMKI, the tissue distribution pattern of CaMKIV is rather limited, with expression restricted primarily to discrete regions of the brain, T-lymphocytes, and post-meiotic germ cells [20], [21], [22], [23].
Gene_expression (expression) of CaMKI in brain
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.17 Pain Relevance 0.16
Generation of hTF-KI transgenic mice has been previously described [16].
Gene_expression (Generation) of hTF-KI associated with targeted disruption
4) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 0.96 Pain Relevance 0.11
However instead of using non-human primates, we developed human TF knock-in (hTF-KI) transgenic mice, which express human TF instead of murine TF (mTF).
Gene_expression (express) of hTF-KI associated with targeted disruption
5) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 1.13 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox