INT22067

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.74
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL2RB) plasma membrane (IL2RB) protein complex assembly (IL2RB)
Anatomy Link Frequency
IL2R 1
IL2RB (Homo sapiens)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 4 99.96 Very High Very High Very High
palliative 2 97.92 Very High Very High Very High
cytokine 4 97.28 Very High Very High Very High
Pain 6 96.04 Very High Very High Very High
imagery 1 92.96 High High
adenocard 3 92.80 High High
Angina 4 84.16 Quite High
vincristine 2 68.16 Quite High
pruritus 6 63.04 Quite High
dexamethasone 2 56.40 Quite High
Disease Link Frequency Relevance Heat
Carpal Tunnel Syndrome 4 99.96 Very High Very High Very High
Mycobacterial Infection 2 99.74 Very High Very High Very High
Cancer 10 99.28 Very High Very High Very High
Pleurisy 2 98.72 Very High Very High Very High
Malignant Neoplastic Disease 7 97.76 Very High Very High Very High
Pleural Effusion 12 96.92 Very High Very High Very High
Amyloidosis 4 96.92 Very High Very High Very High
Metastasis 4 96.52 Very High Very High Very High
Pressure And Volume Under Development 7 96.40 Very High Very High Very High
Sarcoidosis 33 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of Interleukin-2 receptor were elevated during the period of tumour regression but concentrations of other cytokines were normal.
Positive_regulation (elevated) of Interleukin-2 receptor associated with cancer and cytokine
1) Confidence 0.70 Published 1994 Journal Ir J Med Sci Section Abstract Doc Link 7529223 Disease Relevance 0.72 Pain Relevance 0.22
We conclude that a non-specific dialysis-induced activation of epithelial and lymphoid cells rather than a specific immune response could explain the concomitant elevation of IL-2R and TPA serum concentrations in hemodialyzed patients.
Positive_regulation (elevation) of IL-2R
2) Confidence 0.55 Published 1990 Journal Nephron Section Abstract Doc Link 2243570 Disease Relevance 0.25 Pain Relevance 0.09
In 16 patients with carpal tunnel syndrome, increased serum concentrations of IL-2R (p less than 0.005) and TPA (p less than 0.001) were found.
Positive_regulation (increased) of IL-2R associated with carpal tunnel syndrome
3) Confidence 0.55 Published 1990 Journal Nephron Section Abstract Doc Link 2243570 Disease Relevance 0.27 Pain Relevance 0.10
Patients with pronounced cell turnover, reflected by elevated IL-2R and TPA levels, may show an increased susceptibility to dialysis-associated amyloidosis.
Positive_regulation (elevated) of IL-2R associated with amyloidosis
4) Confidence 0.55 Published 1990 Journal Nephron Section Abstract Doc Link 2243570 Disease Relevance 0.34 Pain Relevance 0.08
The serum-soluble interleukin-2 receptor level was also elevated.
Positive_regulation (elevated) of interleukin-2 receptor
5) Confidence 0.37 Published 2005 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 15997786 Disease Relevance 1.39 Pain Relevance 0.17
Elevated IL-2R levels, found in 85% of examined patients, correlated with elevated TPA serum concentrations (p less than 0.05).
Positive_regulation (Elevated) of IL-2R
6) Confidence 0.37 Published 1990 Journal Nephron Section Abstract Doc Link 2243570 Disease Relevance 0.23 Pain Relevance 0.07
His general condition worsened in spite of anti-tuberculosis therapy and soluble interleukin-2 receptor (sIL-2R) was elevated.
Positive_regulation (elevated) of soluble interleukin-2 receptor associated with mycobacterial infection
7) Confidence 0.34 Published 2006 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 17233392 Disease Relevance 0.87 Pain Relevance 0.19
Arginine butyrate is a histone deacetylase (HDAC) inhibitor that also has been shown to increase IL2R-beta (CD122) subunit gene and protein expression.37 While low dose arginine butyrate showed no growth inhibitor effect of its own, combination studies with denileukin diftitox in vitro showed an increase in cytotoxicity.
Positive_regulation (increase) of CD122 in IL2R
8) Confidence 0.17 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.59 Pain Relevance 0.06
A laboratory examination disclosed elevated levels of serum lactate dehydrogenase and soluble interleukin 2 receptor.
Positive_regulation (elevated) of interleukin 2 receptor
9) Confidence 0.13 Published 1999 Journal Rinsho Ketsueki Section Abstract Doc Link 10199209 Disease Relevance 0.47 Pain Relevance 0.14
Two groups of patients were detected: group A, 11 patients who had high levels of soluble interleukin-2 receptor (sIL-2R) before PTCA that decreased toward normal during the follow-up period in most of them; and group B, 13 patients who did not have elevated sIL-2R levels before PTCA and in whom sIL-2R levels did not change after the procedure.
Neg (not) Positive_regulation (elevated) of sIL-2R
10) Confidence 0.10 Published 1995 Journal Circulation Section Body Doc Link 7805203 Disease Relevance 0 Pain Relevance 0
Soluble Interleukin2 receptor: 4133 U/ml (normal value: 220–710 U/ml) were elevated.
Positive_regulation (elevated) of Interleukin2 receptor
11) Confidence 0.03 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2241629 Disease Relevance 0.62 Pain Relevance 0.10

General Comments

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