INT22068

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Context Info
Confidence 0.41
First Reported 1982
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 53
Total Number 58
Disease Relevance 6.14
Pain Relevance 17.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL) endosome (CALCRL) endoplasmic reticulum (CALCRL)
plasma membrane (CALCRL) lysosome (CALCRL) signal transducer activity (CALCRL)
Anatomy Link Frequency
bar 2
brain 2
cleavage 1
thumb 1
CALCRL (Homo sapiens)
CALCRL - Q280H (1)
Pain Link Frequency Relevance Heat
opioid receptor 91 100.00 Very High Very High Very High
Inflammation 24 100.00 Very High Very High Very High
opiate 19 100.00 Very High Very High Very High
Calcitonin gene-related peptide 18 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
GABA receptor 6 100.00 Very High Very High Very High
gABA 59 99.96 Very High Very High Very High
Enkephalin 35 99.88 Very High Very High Very High
Opioid 80 99.82 Very High Very High Very High
Morphine 491 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 27 100.00 Very High Very High Very High
Drug Dependence 20 98.48 Very High Very High Very High
Neuroblastoma 12 96.52 Very High Very High Very High
Bordatella Infection 24 94.84 High High
Disease 40 91.12 High High
Prolactinoma 3 85.88 High High
Migraine Disorders 2 84.88 Quite High
Colon Cancer 29 83.64 Quite High
Anxiety Disorder 16 82.92 Quite High
Osteoporosis 82 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mu agonists such as morphine and fentanyl display a very low affinity for delta and kappa receptor.
receptor Binding (affinity) of associated with mu agonist and morphine
1) Confidence 0.41 Published 1995 Journal Masui Section Abstract Doc Link 8523655 Disease Relevance 0 Pain Relevance 0.97
Central to functional binding of these neuropeptides is the G-protein-coupled receptor, the calcitonin receptor-like receptor (CRLR), whose cell surface expression and pharmacology is determined by coexpression of a receptor activity-modifying protein (RAMP).
CRLR Binding (binding) of associated with neuropeptide
2) Confidence 0.37 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.22
Central to functional binding of these neuropeptides is the G-protein-coupled receptor, the calcitonin receptor-like receptor (CRLR), whose cell surface expression and pharmacology is determined by coexpression of a receptor activity-modifying protein (RAMP).
receptor Binding (binding) of associated with neuropeptide
3) Confidence 0.32 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.21
Central to functional binding of these neuropeptides is the G-protein-coupled receptor, the calcitonin receptor-like receptor (CRLR), whose cell surface expression and pharmacology is determined by coexpression of a receptor activity-modifying protein (RAMP).
receptor Binding (binding) of associated with neuropeptide
4) Confidence 0.32 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.22
Most ligands identified as specific agonists are in fact only selective and appear to interact at more than one receptor type.
receptor Binding (interact) of associated with agonist
5) Confidence 0.31 Published 1995 Journal Masui Section Abstract Doc Link 8523655 Disease Relevance 0 Pain Relevance 0.91
The crystal structure of the extracellular portion of human RAMP1 placed tryptophan-74 in a hydrophobic patch hypothesized to interact with CGRP receptor ligands and also identified nearby residues that may be important for ligand binding.
CGRP receptor Binding (interact) of associated with calcitonin gene-related peptide
6) Confidence 0.30 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20188075 Disease Relevance 0.16 Pain Relevance 0.85
Only a few different classes of structures are currently known as ligands for the GABA recognition site on the hetero-pentameric GABA(A) receptor complex, reflecting the very strict structural requirements for GABA(A) receptor recognition and activation.
) receptor Binding (recognition) of associated with gaba
7) Confidence 0.27 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451401 Disease Relevance 0 Pain Relevance 0.83
The present data suggest a role for the C-terminal intracellular receptor domain in modifying ketanserin/5-HT(1B) receptor interactions.
receptor Binding (interactions) of
8) Confidence 0.21 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10704941 Disease Relevance 0 Pain Relevance 0.18
The antagonists ketanserin and ritanserin are likely to bind the h5-HT1D receptor by its second extracellular loop, near the exofacial surface of the fifth transmembrane domain, or both.
receptor Spec (likely) Binding (bind) of associated with antagonist
9) Confidence 0.18 Published 1998 Journal Mol. Pharmacol. Section Abstract Doc Link 9855638 Disease Relevance 0 Pain Relevance 0.36
These results provide molecular validity for the interaction of OGF and OGF receptor in the regulation of growth processes in humans.
OGF receptor Binding (interaction) of
10) Confidence 0.17 Published 2000 Journal Brain Res. Section Abstract Doc Link 10677613 Disease Relevance 0.14 Pain Relevance 0.25
Receptor variants exist in the human population and indicate possible associations between somatic mutations in the 5-HT(2C) receptor and psychopathology or response to drug treatment.
receptor Binding (associations) of
11) Confidence 0.11 Published 1998 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15991903 Disease Relevance 0.70 Pain Relevance 0.37
Several of these are associated with altered receptor function and individuals at risk for drug abuse.
receptor Binding (associated) of associated with drug abuse
12) Confidence 0.11 Published 2002 Journal Pharmacogenomics Section Abstract Doc Link 11972443 Disease Relevance 0.26 Pain Relevance 0.40
[Met5]enkephalin) and contains the zeta receptor known to be associated with growth, the effects of opioid receptor blockade by naltrexone, a potent opioid antagonist, was examined.
receptor Binding (associated) of associated with antagonist, opioid receptor, enkephalin and opioid
13) Confidence 0.07 Published 1990 Journal Neuroscience Section Abstract Doc Link 2243594 Disease Relevance 0.25 Pain Relevance 0.73
[Met5]enkephalin) and contains the zeta receptor known to be associated with growth, the effects of opioid receptor blockade by naltrexone, a potent opioid antagonist, was examined.
receptor Spec (examined) Binding (contains) of associated with antagonist, opioid receptor, enkephalin and opioid
14) Confidence 0.07 Published 1990 Journal Neuroscience Section Abstract Doc Link 2243594 Disease Relevance 0.25 Pain Relevance 0.73
While the B(2)receptor subtype, constitutively expressed in various tissues, is believed to mediate most of the physiological actions of kinins in healthy conditions, the B(1) receptor, highly regulated during inflammation, has been associated with the sustained actions of these peptides in various pathological situations.
receptor Binding (associated) of associated with inflammation
15) Confidence 0.03 Published 2006 Journal Curr Top Med Chem Section Abstract Doc Link 16918454 Disease Relevance 0.24 Pain Relevance 0.22
The delta receptor binding was reduced in epileptic focus obtained from patients with epilepsy secondary to cerebral lesion (-25%) and surrounding areas (-31%).
receptor Binding (binding) of
16) Confidence 0.03 Published 2002 Journal Epilepsia Section Body Doc Link 12121327 Disease Relevance 0.24 Pain Relevance 0
Cross-competition studies indicated that this effect was not due to the interaction of opiates with the dopaminergic receptor.
dopaminergic receptor Binding (interaction) of associated with opiate
17) Confidence 0.03 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2995431 Disease Relevance 0.30 Pain Relevance 1.04
Incubations with [3H]ethylketo-cyclazocine (EKC) at increasing doses revealed the presence of high affinity, low capacity, opioid peptide receptor-specific binding of the kappa-type.
receptor Binding (binding) of associated with opioid
18) Confidence 0.02 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2892853 Disease Relevance 0 Pain Relevance 0.23
A phylogenetic analysis of Ciona sequence (ci0100148288) with vertebrate type C INSL3/Relaxin receptors (Figure 4) revealed that the Ciona receptor is not orthologous to vertebrate type C LGRs and is therefore unlikely to bind to vertebrate INSL3/Relaxin versions.
receptor Binding (bind) of
19) Confidence 0.02 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0.08 Pain Relevance 0
In vertebrate INSL3/relaxin binding GPCRs, a combination of a single cysteine-rich LDL-A domain and multiple LRRs at the ectodomain site is necessary for ligand binding, receptor activation and further downstream signalling from these receptors [45].
receptor Binding (binding) of
20) Confidence 0.02 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0

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