INT22069

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Context Info
Confidence 0.70
First Reported 1986
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.61
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
substantia nigra 6
nerves 2
nucleus 2
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Substantia nigra 41 100.00 Very High Very High Very High
Sumatriptan 10 98.60 Very High Very High Very High
antagonist 6 98.04 Very High Very High Very High
agonist 6 96.72 Very High Very High Very High
Eae 2 95.08 Very High Very High Very High
tetrodotoxin 2 90.72 High High
Action potential 1 74.80 Quite High
sodium channel 1 67.20 Quite High
Bile 4 62.16 Quite High
anesthesia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cirrhosis 19 100.00 Very High Very High Very High
Neuroblastoma 2 90.24 High High
Congenital Anomalies 1 76.68 Quite High
Liver Disease 8 71.68 Quite High
Hepatic Encephalopathy 17 54.48 Quite High
Liver Failure 10 54.48 Quite High
Cognitive Disorder 11 41.08 Quite Low
Urological Neuroanatomy 7 5.00 Very Low Very Low Very Low
Hyperammonemia 4 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, following administration of gamma-hydroxybutyrate, there was a large Ca2+ dependent increase in release of acetylcholinesterase in the substantia nigra.
Positive_regulation (increase) of Localization (release) of acetylcholinesterase in substantia nigra associated with substantia nigra
1) Confidence 0.70 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.37
Application of exogenous 5-hydroxytryptamine (5-HT) directly to the substantia nigra similarly enhanced release of AChE, whilst local application of cinanserin, a 5-HT antagonist, inhibited electrically-evoked release.
Positive_regulation (enhanced) of Localization (lease o) of AChE in substantia nigra associated with antagonist and substantia nigra
2) Confidence 0.49 Published 1994 Journal Neuroreport Section Abstract Doc Link 8018847 Disease Relevance 0 Pain Relevance 0.40
In this study we have attempted to identify the 5-HT receptor subtype mediating release of acetylcholinesterase (AChE) from nigral neurones, measured by assay of perfusate obtained via chronically implanted push-pull cannulae.
Positive_regulation (mediating) of Localization (lease o) of AChE
3) Confidence 0.49 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 8532190 Disease Relevance 0 Pain Relevance 0.18
Drugs which inhibited raphé-stimulated release of AChE had no effect on concomitant animal rotation, indicating that the behavioural events are mediated via distinct processes, unrelated to those mediating nigral AChE release.
Positive_regulation (raphé-stimulated) of Localization (release) of AChE
4) Confidence 0.49 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 8532190 Disease Relevance 0 Pain Relevance 0.43
Application of submicromolar concentrations of 5-HT, 2,5,-dimethoxy-4- iodoamphetamine and alpha-methyl-5-HT significantly enhanced release of AChE, whereas 5-carboxamidotryptamine, sumatriptan, 2-methyl-5-HT and 5-methoxytryptamine were ineffective at a similar concentration range.
Positive_regulation (enhanced) of Localization (release) of AChE associated with sumatriptan
5) Confidence 0.49 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 8532190 Disease Relevance 0 Pain Relevance 0.28
Although all three treatments were accompanied by an increase in acetylcholinesterase release within the substantia nigra, potassium-evoked release did not cause any detectable change in behaviour.
Positive_regulation (increase) of Localization (release) of acetylcholinesterase in substantia nigra associated with substantia nigra
6) Confidence 0.46 Published 1990 Journal Neuroscience Section Abstract Doc Link 2243598 Disease Relevance 0 Pain Relevance 0.29
Simultaneously, a gradual enhancement of acetylcholinesterase cytochemical appearance took place attaining its maximum level by the same time.
Positive_regulation (enhancement) of Localization (appearance) of acetylcholinesterase
7) Confidence 0.46 Published 1988 Journal Tsitologiia Section Abstract Doc Link 2453961 Disease Relevance 0.17 Pain Relevance 0.12
The data suggest that evoked release of AChE from the substantia nigra by stimulation of the dorsal raphé nucleus may be mediated in part via a 5-HT2 receptor type.
Spec (may) Positive_regulation (ed in pa) of Localization (se of A) of AChE in nucleus associated with substantia nigra
8) Confidence 0.45 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 8532190 Disease Relevance 0 Pain Relevance 0.42
Increased AChE in BDL cirrhotic rats leads to a pronounced decrease (?
Positive_regulation (Increased) of Localization (rats) of AChE associated with cirrhosis
9) Confidence 0.43 Published 2008 Journal Brain Section Abstract Doc Link PMC2577805 Disease Relevance 0.44 Pain Relevance 0.03
The results indicate that 5-HT, released from raphé-nigral afferent nerves, enhances the dendritic release of AChE, although this effect is unlikely to be mediated via 5-HT1D receptors.
Positive_regulation (enhances) of Localization (release) of AChE in nerves
10) Confidence 0.43 Published 1994 Journal Neuroreport Section Abstract Doc Link 8018847 Disease Relevance 0 Pain Relevance 0.39

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