INT220699

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.26
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CHRNE) transport (CHRNE) plasma membrane (CHRNE)
Anatomy Link Frequency
neurons 1
CHRNE (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 24 82.20 Quite High
adenocard 14 77.88 Quite High
Inflammation 10 64.00 Quite High
rheumatoid arthritis 2 63.28 Quite High
Glutamate 8 55.68 Quite High
corticosteroid 46 5.00 Very Low Very Low Very Low
Action potential 23 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myasthenia Gravis 339 82.80 Quite High
Disease 37 77.92 Quite High
Thymoma 34 71.60 Quite High
Motor Neuron Diseases 6 67.32 Quite High
Neuropathic Pain 8 64.44 Quite High
INFLAMMATION 6 64.00 Quite High
Rheumatoid Arthritis 2 63.28 Quite High
Systemic Lupus Erythematosus 2 62.40 Quite High
Autoimmune Disease 10 60.92 Quite High
Cancer 2 52.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Approximately 4% of patients with negative AChR binding antibodies have an elevated AChR modulating antibody assay, and approximately 1% of patients with negative AChR binding antibodies demonstrate increased AChR blocking antibodies [29].


Positive_regulation (increased) of AChR
1) Confidence 0.32 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.18 Pain Relevance 0.06
Approximately 4% of patients with negative AChR binding antibodies have an elevated AChR modulating antibody assay, and approximately 1% of patients with negative AChR binding antibodies demonstrate increased AChR blocking antibodies [29].


Positive_regulation (elevated) of AChR
2) Confidence 0.32 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.08 Pain Relevance 0.06
Parri, personal communication), potentially explaining the facilitatory effect of mGluR and AchR activation in this study, whereas the presence of a slow ‘wave-like’ co-activation of different neurons (i.e.
Positive_regulation (activation) of AchR in neurons
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637539 Disease Relevance 0 Pain Relevance 0.14
Furthermore, following this more intense mGluR or AchR activation, recurrent episodes of firing were of a higher mean frequency (peak firing rate: 39.8.7±3.8 Hz; p<0.01; n?
Positive_regulation (activation) of AchR
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637539 Disease Relevance 0 Pain Relevance 0
As with the previously described human V790M mutation, both M605I and A727V showed reduced expression in HEK cells, however, the ability of each of the mutants to induce AChR aggregation in response to agrin in MuSK?
Positive_regulation (induce) of AChR
5) Confidence 0.02 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0 Pain Relevance 0

General Comments

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