INT220700

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 6.67
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MUSK) plasma membrane (MUSK)
Anatomy Link Frequency
plasma 6
juvenile 1
a band 1
MUSK (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 73.36 Quite High
Inflammation 21 26.64 Quite Low
rheumatoid arthritis 13 25.92 Quite Low
imagery 8 18.96 Low Low
Multiple sclerosis 11 12.80 Low Low
corticosteroid 46 5.00 Very Low Very Low Very Low
Calcium channel 22 5.00 Very Low Very Low Very Low
tolerance 17 5.00 Very Low Very Low Very Low
Action potential 14 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myasthenia Gravis 633 100.00 Very High Very High Very High
Shock 22 100.00 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 22 99.04 Very High Very High Very High
Autoimmune Disease 65 97.68 Very High Very High Very High
Muscle Hypotonia 2 97.64 Very High Very High Very High
Disease 245 95.24 Very High Very High Very High
Thymoma 34 93.16 High High
Cancer 68 91.96 High High
Fatigue 2 74.24 Quite High
Pain 2 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover MuSK was the only surface membrane protein detected in any of the immunoprecipitates and was only found in the MuSK antibody-positive samples; no other membrane protein would have been erroneously assigned as a potential antigen target.
Gene_expression (found) of MuSK
1) Confidence 0.75 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.24 Pain Relevance 0
On each occasion, MuSK was specifically and robustly detected as the only identifiable plasma membrane protein in each of the three patient samples (see Fig. 4 for examples of two MuSK peptides).
Gene_expression (detected) of MuSK in plasma
2) Confidence 0.75 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.46 Pain Relevance 0
As a model system we used a muscle cell line, TE671, that endogenously expresses muscle-specific tyrosine receptor kinase (MuSK) and sera or plasmas from patients with a subtype of the autoimmune disease myasthenia gravis in which patients have autoantibodies against MuSK.
Gene_expression (expresses) of MuSK in plasmas associated with autoimmune disease and myasthenia gravis
3) Confidence 0.75 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Abstract Doc Link PMC2716719 Disease Relevance 0.46 Pain Relevance 0
MuSK was robustly detected as the only membrane protein in immunoprecipitates from all three patient samples tested and not from the three MuSK antibody-negative control samples processed in parallel.
Gene_expression (detected) of MuSK
4) Confidence 0.75 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Abstract Doc Link PMC2716719 Disease Relevance 0.48 Pain Relevance 0
The results (Fig. 2b) show that three MuSK-MG samples immunoprecipitated a band of ?
Gene_expression (samples) of MuSK-MG in a band associated with myasthenia gravis
5) Confidence 0.65 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.33 Pain Relevance 0
l (diluted 20-fold in DMEM) of one MuSK-MG plasma (shown by radioimmunoprecipitation assay to bind to 1.24 ng of MuSK/?
Gene_expression (/) of MuSK in plasma associated with myasthenia gravis
6) Confidence 0.65 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.30 Pain Relevance 0
Apart from MuSK itself, many of the proteins, including heat shock proteins, ribonucleoproteins, and tubulin, were present in both patient and control immunoprecipitates.
Gene_expression (present) of MuSK associated with shock
7) Confidence 0.65 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.36 Pain Relevance 0
On each occasion, MuSK was specifically and robustly detected as the only identifiable plasma membrane protein in each of the three patient samples (see Fig. 4 for examples of two MuSK peptides).
Gene_expression (was) of MuSK in plasma
8) Confidence 0.65 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.46 Pain Relevance 0
For this model, we demonstrated the presence of the membrane protein MuSK in immunoprecipitates from three patients with myasthenia and in none of the control samples.
Gene_expression (presence) of MuSK
9) Confidence 0.58 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.19 Pain Relevance 0
l (diluted 20-fold in DMEM) of one MuSK-MG plasma (shown by radioimmunoprecipitation assay to bind to 1.24 ng of MuSK/?
Gene_expression (plasma) of MuSK-MG in plasma associated with myasthenia gravis
10) Confidence 0.57 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.31 Pain Relevance 0
l of MuSK-MG plasma (with a maximum MuSK binding capacity of 62 ng) immunoprecipitated ?
Gene_expression (plasma) of MuSK-MG in plasma associated with myasthenia gravis
11) Confidence 0.57 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.21 Pain Relevance 0
It may be difficult to make the distinction between juvenile MG and congenital MG, particularly in the absence of AChR or MuSK antibodies, or a clear history of ptosis and other manifestations of hypotonia from the time of birth that would suggest genetic disease.
Gene_expression (antibodies) of MuSK in juvenile associated with muscle hypotonia, myasthenia gravis, ocular toxicity (including many sub-types) and disease
12) Confidence 0.50 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.77 Pain Relevance 0.07
MuSK antibodies
Gene_expression (antibodies) of MuSK
13) Confidence 0.50 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.09 Pain Relevance 0

General Comments

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