INT22071

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 5.44
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG)
nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)
Anatomy Link Frequency
plasma 4
osteocytes 4
leukocytes 2
endothelial cells 2
chondrocytes 1
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 20 100.00 Very High Very High Very High
Acute pain 3 99.56 Very High Very High Very High
endometriosis 6 98.92 Very High Very High Very High
Central nervous system 3 98.60 Very High Very High Very High
opioid receptor 27 97.40 Very High Very High Very High
IPN 30 97.08 Very High Very High Very High
addiction 6 96.24 Very High Very High Very High
depression 3 95.20 Very High Very High Very High
Inflammation 69 89.92 High High
Hyperalgesia 33 89.92 High High
Disease Link Frequency Relevance Heat
Stress 44 99.98 Very High Very High Very High
Pain 27 99.56 Very High Very High Very High
Endometriosis 13 98.92 Very High Very High Very High
Eclampsia 6 97.64 Very High Very High Very High
Inflammatory Pain 30 97.08 Very High Very High Very High
Adhesions 50 96.40 Very High Very High Very High
Respiratory Failure 3 95.20 Very High Very High Very High
Vomiting 3 94.24 High High
Pre-eclampsia 100 93.68 High High
Obesity 24 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that the expression of endoglin and S100A13 corresponds to the activation of the endothelial cells in the process of endometriotic angiogenesis, suggesting a beneficial role for these two molecules as markers for actively progressing endometriotic process.
Positive_regulation (corresponds) of Gene_expression (expression) of endoglin in endothelial cells associated with endometriosis
1) Confidence 0.50 Published 2005 Journal Reprod Biol Section Abstract Doc Link 15821778 Disease Relevance 0.93 Pain Relevance 0.36
These results indicate that: 1. secretion of beta-END-LI varies during different phases of the estrous cycle, 2. acute stress is a potent activator for beta-END-LI secretion, 3. no apparent increase of beta-END-LI in the blood plasma of ewes subjected to prolonged stress concomitant with accumulation of this material in pituitary (Polkowska and Przekop, 1988) supports the idea, that prolonged stress augments the synthesis of beta-END-LI but not its release.
Positive_regulation (augments) of Gene_expression (synthesis) of END in plasma associated with stress
2) Confidence 0.49 Published 1990 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2245820 Disease Relevance 0.43 Pain Relevance 0
Increasing frusemide concentrations were correlated with increased sEng production in normal pregnancy (P < 0.005). 5.
Positive_regulation (increased) of Gene_expression (production) of sEng
3) Confidence 0.40 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.40 Pain Relevance 0.06
In contrast, patients with acute pain showed significantly increased levels of beta-End in plasma.
Positive_regulation (increased) of Gene_expression (levels) of beta-End in plasma associated with acute pain
4) Confidence 0.37 Published 1988 Journal Rev. Esp. Fisiol. Section Abstract Doc Link 2972025 Disease Relevance 0.28 Pain Relevance 0.36
Rana et al. (2007) found that although levels of sEng and sFLT-1 were found to be elevated in the serum of preeclamptic women at 17-20 weeks gestation when compared to controls, the levels at 11-13 weeks were similar between cases and controls.
Positive_regulation (elevated) of Gene_expression (levels) of sEng
5) Confidence 0.26 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 0.68 Pain Relevance 0
According to the recruitment maneuver used, the zero end-expiratory pressure (ZEEP) group (n = 22) received the vital capacity maneuver (VCM) maintained for 7-8 s applied immediately after intubation plus ZEEP; the positive end-expiratory pressure (PEEP) 5 group (n = 22) received the VCM maintained for 7-8 s applied immediately after intubation plus 5 cm H(2)O of PEEP; and the PEEP 10 group (n = 22) received the VCM maintained for 7-8 s applied immediately after intubation plus 10 cm H(2)O of PEEP.
Positive_regulation (According) of Gene_expression (pressure) of end-expiratory
6) Confidence 0.22 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843790 Disease Relevance 0.27 Pain Relevance 0
According to the recruitment maneuver used, the zero end-expiratory pressure (ZEEP) group (n = 22) received the vital capacity maneuver (VCM) maintained for 7-8 s applied immediately after intubation plus ZEEP; the positive end-expiratory pressure (PEEP) 5 group (n = 22) received the VCM maintained for 7-8 s applied immediately after intubation plus 5 cm H(2)O of PEEP; and the PEEP 10 group (n = 22) received the VCM maintained for 7-8 s applied immediately after intubation plus 10 cm H(2)O of PEEP.
Positive_regulation (According) of Gene_expression (pressure) of end-expiratory
7) Confidence 0.22 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843790 Disease Relevance 0.27 Pain Relevance 0
According to the recruitment maneuver used, the zero end-expiratory pressure (ZEEP) group (n = 22) received the vital capacity maneuver (VCM) maintained for 7-8 s applied immediately after intubation plus ZEEP; the positive end-expiratory pressure (PEEP) 5 group (n = 22) received the VCM maintained for 7-8 s applied immediately after intubation plus 5 cm H(2)O of PEEP; and the PEEP 10 group (n = 22) received the VCM maintained for 7-8 s applied immediately after intubation plus 10 cm H(2)O of PEEP.
Positive_regulation (positive) of Gene_expression (pressure) of end-expiratory
8) Confidence 0.22 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843790 Disease Relevance 0.24 Pain Relevance 0
These cells displayed spindle-shape morphology and were identified by their expression for CD73, CD105, CD90 but negative for all hematopoietic markers (CD45, CD34, HLA-Dr).
Positive_regulation (negative) of Gene_expression (expression) of CD105
9) Confidence 0.13 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.18 Pain Relevance 0.04
g) also enhanced END content in leukocytes, however, a significant effect was observed only after 25 ?
Positive_regulation (enhanced) of Gene_expression (content) of END in leukocytes
10) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.05 Pain Relevance 0.05
For example, even though the control END levels in Fig. 4A and Fig. 4B were comparable, the END levels after different doses of POMC-MIDGE-NLS varied between the two graphs.
Positive_regulation (varied) of Gene_expression (levels) of END
11) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.54 Pain Relevance 0.39
Our major objective was to enhance the production and release of END in inflamed tissue using POMC-MIDGE-NLS to provide continuous relief of inflammatory pain.


Positive_regulation (enhance) of Gene_expression (production) of END associated with ipn
12) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.70 Pain Relevance 0.97
plastic-adherent under standard culture conditions;positive for expression of CD105, CD73, and CD90, and absent for expression of hematopoietic cell surface markers CD34, CD45, CD11a, CD19, and HLA-DR;under specific stimulus, cells should differentiate into osteocytes, adipocytes, and chondrocytes in vitro.
Positive_regulation (positive) of Gene_expression (expression) of CD105 in osteocytes associated with obesity
13) Confidence 0.05 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962904 Disease Relevance 0.16 Pain Relevance 0
plastic-adherent under standard culture conditions;positive for expression of CD105, CD73, and CD90, and absent for expression of hematopoietic cell surface markers CD34, CD45, CD11a, CD19, and HLA-DR;under specific stimulus, cells should differentiate into osteocytes, adipocytes, and chondrocytes in vitro.
Positive_regulation (positive) of in chondrocytes Gene_expression (expression) of CD105 in osteocytes associated with obesity
14) Confidence 0.02 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962904 Disease Relevance 0.16 Pain Relevance 0
plastic-adherent under standard culture conditions;positive for expression of CD105, CD73, and CD90, and absent for expression of hematopoietic cell surface markers CD34, CD45, CD11a, CD19, and HLA-DR;under specific stimulus, cells should differentiate into osteocytes, adipocytes, and chondrocytes in vitro.
Positive_regulation (positive) of in adipocytes Gene_expression (expression) of CD105 in osteocytes associated with obesity
15) Confidence 0.02 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962904 Disease Relevance 0.16 Pain Relevance 0
These results indicate a possible functional relationship between increased pineal activity (as a result of short photoperiod) and increased MBH met-enkephalin, LHRH, and serum beta-end LI levels.
Spec (possible) Positive_regulation (increased) of Gene_expression (levels) of beta-end associated with enkephalin
16) Confidence 0.01 Published 1984 Journal J. Pineal Res. Section Abstract Doc Link 6100720 Disease Relevance 0 Pain Relevance 0.39

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox