INT220732

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.61
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
nervous systems 1
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 82 97.72 Very High Very High Very High
tetrodotoxin 23 91.68 High High
amygdala 34 91.52 High High
Dopamine 46 86.08 High High
c fibre 12 68.28 Quite High
Dorsal horn 17 66.16 Quite High
Nav1.7 13 61.52 Quite High
fifth nerve 1 55.12 Quite High
antagonist 12 53.44 Quite High
unmyelinated 16 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 4 84.96 Quite High
Reprotox - General 1 54 84.40 Quite High
Nociception 4 70.64 Quite High
Ganglion Cysts 11 5.00 Very Low Very Low Very Low
Aids-related Complex 7 5.00 Very Low Very Low Very Low
Metastasis 3 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro evidence suggesting differential ER degradation following estradiol and PKA activation [60] supports this idea.
Protein_catabolism (degradation) of PKA
1) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.37
Gravin is expressed in an extensive array of tissue including fibroblasts, vascular endothelium, neural crest derived cells, and portions of the central (cerebellum) and peripheral (peripheral nerve, myenteric plexus and satellite cells) nervous systems [7] SSeCKS (previously identified as clone 72, [8]) has been characterized as a substrate of PKC, PKA or rho family members [9-11].
Protein_catabolism (family) of PKA in nervous systems
2) Confidence 0.02 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.16 Pain Relevance 0.13
It is possible that VGSC expression/activity was controlled at a variety of levels from transcription to post-translation, including mRNA stability and phosphorylation by PKC or PKA [e.g. [33]].
Protein_catabolism (stability) of PKA associated with sodium channel
3) Confidence 0.02 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.45 Pain Relevance 0.52

General Comments

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