INT220740

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) signal transduction (EGF) extracellular space (EGF)
extracellular region (EGF) plasma membrane (EGF) cytoplasm (NAV1)
Anatomy Link Frequency
plasma 2
EGF (Homo sapiens)
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 13 100.00 Very High Very High Very High
sodium channel 82 99.52 Very High Very High Very High
antagonist 1 93.28 High High
tetrodotoxin 23 11.12 Low Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 54 95.32 Very High Very High Very High
Adhesions 3 74.32 Quite High
Cancer 2 41.40 Quite Low
Metastasis 3 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 1 5.00 Very Low Very Low Very Low
Pheochromocytoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our essential result and hypothesis to follow are that EGF induced upregulation of Nav1.7 mRNA and VGSC protein synthesis, most of which was inserted in plasma membrane and led to the observed enhancement of MCBs.
EGF Positive_regulation (induced) of Regulation (upregulation) of Nav1 in plasma associated with sodium channel and nav1.7
1) Confidence 0.31 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.61 Pain Relevance 0.32

General Comments

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