INT220744

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
Golgi apparatus (KRT20) plasma membrane (EGF) cytoplasm (KRT20)
Anatomy Link Frequency
plasma 4
EGF (Homo sapiens)
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 164 100.00 Very High Very High Very High
Nav1.7 26 100.00 Very High Very High Very High
antagonist 2 93.28 High High
Nerve growth factor 12 45.24 Quite Low
tetrodotoxin 46 13.84 Low Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 108 95.32 Very High Very High Very High
Adhesions 6 77.04 Quite High
Metastasis 6 53.32 Quite High
Cancer 4 41.40 Quite Low
Anaplastic Astrocytoma 2 41.16 Quite Low
Pheochromocytoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our essential result and hypothesis to follow are that EGF induced upregulation of Nav1.7 mRNA and VGSC protein synthesis, most of which was inserted in plasma membrane and led to the observed enhancement of MCBs.
EGF Positive_regulation (induced) of Gene_expression (synthesis) of VGSC protein in plasma associated with sodium channel and nav1.7
1) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.62 Pain Relevance 0.32
Importantly, under conditions when VGSC activity was blocked, upregulation of VGSC protein expression (total or in plasma membrane) by EGF was not seen.
EGF Positive_regulation (upregulation) of Gene_expression (expression) of VGSC protein in plasma associated with sodium channel
2) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.64 Pain Relevance 0.57

General Comments

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