INT22075

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Context Info
Confidence 0.64
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.70
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNA2) extracellular region (IFNA2) cell-cell signaling (IFNA2)
Anatomy Link Frequency
Joint 2
lymph nodes 2
endometrium 2
stem cell 2
CNS 2
IFNA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 47 99.98 Very High Very High Very High
Central nervous system 4 99.68 Very High Very High Very High
opiate 1 94.32 High High
Morphine 5 93.36 High High
peripheral neuropathy 4 92.36 High High
Pain 4 82.96 Quite High
Inflammation 20 78.32 Quite High
rheumatoid arthritis 22 77.20 Quite High
Sicca syndrome 2 74.00 Quite High
alcohol 1 73.96 Quite High
Disease Link Frequency Relevance Heat
Arthritis 64 99.98 Very High Very High Very High
Disease 17 99.80 Very High Very High Very High
Psychosis 2 99.44 Very High Very High Very High
Hepatitis C Virus Infection 27 99.24 Very High Very High Very High
Cryoglobulinemia 7 98.44 Very High Very High Very High
Hyperplasia 1 97.64 Very High Very High Very High
Arthropathy 5 96.98 Very High Very High Very High
Infection 38 95.60 Very High Very High Very High
Peripheral Neuropathy 4 92.36 High High
Toxicity 1 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Psychosis results from in situ viral stimulation of aIFN production in the CNS of a vulnerable host having defective regulation of either sensitivity or production.
Positive_regulation (stimulation) of Gene_expression (production) of aIFN in CNS associated with psychosis and central nervous system
1) Confidence 0.64 Published 1990 Journal J. Nerv. Ment. Dis. Section Abstract Doc Link 2246646 Disease Relevance 0.81 Pain Relevance 0.28
Finally the production of interferon-alpha and of prostaglandin E2 induced by stimulation of the cells with endotoxin (LPS) was diminished.
Positive_regulation (induced) of Gene_expression (production) of interferon-alpha
2) Confidence 0.42 Published 1997 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 9278179 Disease Relevance 0.08 Pain Relevance 0.41
The immune response initiated by induced production of IFN-alpha and TFN-alpha is specifically aimed at an infectious antigen and appears mediated (in part) by enhanced migration of Langerhans' cells to regional lymph nodes.
Positive_regulation (induced) of Gene_expression (production) of IFN-alpha in lymph nodes
3) Confidence 0.16 Published 2003 Journal Dermatol Clin Section Abstract Doc Link 12757252 Disease Relevance 0.23 Pain Relevance 0.06
He received alpha-interferon at a dose of 1.8 million units/day 5 times a week by subcutaneous injections as adjuvant immunotherapy post autologous stem cell transplant.
Positive_regulation (received) of Gene_expression (received) of alpha-interferon in stem cell
4) Confidence 0.15 Published 1999 Journal Pediatr Hematol Oncol Section Abstract Doc Link 10599097 Disease Relevance 0.49 Pain Relevance 0.23
Joint manifestations in patients with chronic HCV infection can be encountered in four different forms: a coexistent arthropathy (not related to HCV), arthritis in the setting of mixed cryoglobulinemia, arthritis directly related to HCV (HCV-associated arthritis), and arthritis induced by antiviral therapy (interferon-alpha [IFN-?])
Positive_regulation (induced) of Gene_expression (therapy) of interferon-alpha in Joint associated with cryoglobulinemia, arthropathy, hepatitis c virus infection, infection and arthritis
5) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592818 Disease Relevance 3.10 Pain Relevance 0.47
However, immediately on extending the light and up until 1 week after transfer to sea water, 26 of the 90 fish sampled showed up-regulated expression for IFNalpha, Mx and gammaIP.
Positive_regulation (up-regulated) of Gene_expression (expression) of IFNalpha
6) Confidence 0.01 Published 2007 Journal Fish Shellfish Immunol. Section Abstract Doc Link 17467293 Disease Relevance 0 Pain Relevance 0
Ectopic MNCs of women with adenomyosis produced higher levels of IFNgamma, IFNalpha and TNFalpha than the MNCs of normal endometrium.
Positive_regulation (levels) of Gene_expression (produced) of IFNalpha in endometrium
7) Confidence 0.00 Published 2002 Journal Am. J. Reprod. Immunol. Section Body Doc Link 12069392 Disease Relevance 0 Pain Relevance 0

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