INT220767

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.00
Pain Relevance 0.16

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nucleoplasm (Tert) chromosome (Tert) RNA binding (Tert)
nucleus (Tert) DNA binding (Tert) nucleotidyltransferase activity (Tert)
Anatomy Link Frequency
skin 3
Tert (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 28 90.76 High High
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 175 97.64 Very High Very High Very High
Alopecia 238 92.20 High High
Skin Abnormalities 7 89.20 High High
Adhesions 14 77.24 Quite High
Aging 14 71.04 Quite High
Lifespan 7 69.56 Quite High
Cancer 35 59.04 Quite High
Hyperplasia 7 36.08 Quite Low
Injury 7 34.88 Quite Low
Body Weight 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significance analysis of microarrays (SAM) was applied to our time course microarray data to yield the genes differentially regulated in TERT-on and TERT-off samples (false discovery rate [FDR] < 0.05) [31].
Regulation (regulated) of TERT
1) Confidence 0.53 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.05
Unsupervised clustering of both samples and genes revealed that the t = 0 samples from TERT-off mice were more closely related to TERT-on mice, indicating that changes in TERT levels, rather than other variables, underlie these gene expression changes (Figure S4).
Regulation (changes) of TERT
2) Confidence 0.39 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.04
Our data suggest that TERT is an important developmental regulator in mouse skin, linking TERT to the Wnt and Myc networks, critical signaling pathways for epidermal development.
Regulation (regulator) of TERT in skin
3) Confidence 0.27 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.36 Pain Relevance 0
To achieve conditional regulation of either wild-type mouse TERT or mouse TERTci in skin, we crossed tetop-TERT+ or tetop-TERTci+ mice to a transgenic line that expresses the tetracycline transactivator (tTA) under control of the keratin-5 (K5) promoter [23].
Regulation (nal regula) of TERT in skin associated with targeted disruption
4) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.45 Pain Relevance 0
In designing these experiments, we leveraged several strengths of our system: (1) the ability to study the effects of TERT on the whole organ in vivo (2) temporal control of TERT with doxycycline enabling a study of dynamic gene expression changes over time and (3) a tetracycline-off configuration shown to result in rapid silencing in vivo [30].
Regulation (control) of TERT
5) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.13 Pain Relevance 0.04
Significance analysis of microarrays (SAM) was applied to our time course microarray data to yield the genes differentially regulated in TERT-on and TERT-off samples (false discovery rate [FDR] < 0.05) [31].
Regulation (regulated) of TERT-off
6) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.05
To understand the nature of this RT-independent function for TERT, we studied the genome-wide transcriptional response to acute changes in TERT levels in mouse skin.
Regulation (changes) of TERT in skin
7) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0

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