INT220770

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.09
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) chromosome (Tert) RNA binding (Tert)
nucleus (Tert) DNA binding (Tert) nucleotidyltransferase activity (Tert)
Anatomy Link Frequency
telomere 3
follicles 1
skin 1
hematopoietic cell 1
Tert (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 98.20 Very High Very High Very High
Serotonin 4 93.52 High High
Neuropeptide 1 81.60 Quite High
midbrain 1 78.40 Quite High
Ventral tegmentum 1 75.44 Quite High
Nucleus accumbens 1 59.44 Quite High
Central nervous system 1 48.08 Quite Low
member 8 1 47.00 Quite Low
Action potential 3 22.96 Low Low
sodium channel 11 18.68 Low Low
Disease Link Frequency Relevance Heat
Hematological Disease 176 86.40 High High
Aids-related Complex 1 81.28 Quite High
Helminth Infection 3 69.40 Quite High
Anaemia 40 68.92 Quite High
Cancer 31 68.48 Quite High
Congenital Anomalies 24 65.92 Quite High
Alopecia 106 62.00 Quite High
Apoptosis 147 56.00 Quite High
Cleidocranial Dysplasia 8 49.68 Quite Low
Colon Cancer 3 36.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that TERT acutely causes profound changes in gene expression in mouse skin supports this idea and indicates that TERT is directly or indirectly associated with gene regulation.
TERT Binding (associated) of in skin
1) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0
To independently validate these findings, we prospectively scanned the promoter regions of TERT-regulated genes using TRANSFAC consensus binding sequences for both Myc and TCF/LEF.
TERT-regulated Binding (binding) of
2) Confidence 0.32 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.17 Pain Relevance 0
Importantly, using rigorous ROC statistics, we found that this clear linkage between the TERT signature and the natural genetic program in cycling follicles is independent of the variables used to define the composition of the TERT signature.
TERT Spec (clear) Binding (linkage) of in follicles
3) Confidence 0.31 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.07 Pain Relevance 0
Communication between TCs and presynaptic cells is thought to involve adenosine-5?
TCs Binding (Communication) of associated with adenocard
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0.27
Hence, both the TR binding and RT domains of TERT must act in concert for the synthesis of telomere repeats [13].
TR Binding (binding) of in telomere
5) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.07 Pain Relevance 0
Instead, the RNA-binding domains of TERT interact with TR to facilitate the elongation of the telomere repeats via the catalytic activity of the RT domain [11], [12], [13], [14], [15].
TR Binding (interact) of in telomere
6) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.06 Pain Relevance 0
Each of these domains is required for full activity [6], but the TR-binding and enzymatic RT domains of TERT are particularly critical for telomere maintenance [13].
TR Binding (binding) of in telomere
7) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.39 Pain Relevance 0
These findings from both zTERT and hTERT rescue studies indicate that irrespective of its TR-binding ability and authentic telomerase activity, there are non-canonical functions of the RT domain of TERT which may be particularly essential for hematopoietic cell differentiation and survival.
TR Binding (binding) of in hematopoietic cell
8) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.19 Pain Relevance 0

General Comments

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