INT220774

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.09
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) chromosome (Tert) RNA binding (Tert)
nucleus (Tert) DNA binding (Tert) nucleotidyltransferase activity (Tert)
Tert (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 20 89.44 High High
anesthesia 5 23.04 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 125 100.00 Very High Very High Very High
Adhesions 10 60.16 Quite High
Aging 10 44.88 Quite Low
Lifespan 5 43.40 Quite Low
Alopecia 170 5.00 Very Low Very Low Very Low
Cancer 25 5.00 Very Low Very Low Very Low
Body Weight 10 5.00 Very Low Very Low Very Low
Hyperplasia 5 5.00 Very Low Very Low Very Low
Helminth Infection 5 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TERT expression by Northern blot in the TERT-off cohort was efficiently suppressed by doxycycline injection within 6 hours (Figure 4B).
Negative_regulation (suppressed) of Gene_expression (expression) of TERT
1) Confidence 0.58 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.04
In this tetracycline-off configuration, double transgenic K5-tTA+; tetop-TERT+ mice and K5-tTA+; tetop-TERTci+ mice were treated with doxycycline-drinking water throughout embryogenesis to suppress transgenic TERT expression, then switched to normal water between postnatal days 10–21 to induce TERT expression.
Negative_regulation (suppress) of Gene_expression (expression) of TERT associated with targeted disruption
2) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.63 Pain Relevance 0.03
g/ml) was administered in drinking water throughout development until post-natal day 10–21 to continually suppress transgenic TERT expression during development and allow TERT upregulation to occur postnatally.
Negative_regulation (suppress) of Gene_expression (expression) of TERT associated with targeted disruption
3) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.39 Pain Relevance 0
TERT expression by Northern blot in the TERT-off cohort was efficiently suppressed by doxycycline injection within 6 hours (Figure 4B).
Negative_regulation (suppressed) of Gene_expression (expression) of TERT-off
4) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.04
After induction of these changes, we then administered doxycycline to silence TERT expression, followed by a series of closely spaced serial biopsies.
Negative_regulation (administered) of Gene_expression (expression) of TERT
5) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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