INT220777

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.34
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) chromosome (Tert) RNA binding (Tert)
nucleus (Tert) DNA binding (Tert) nucleotidyltransferase activity (Tert)
Anatomy Link Frequency
skin 4
sebaceous gland 2
epithelial cells 2
Tert (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 48 96.16 Very High Very High Very High
withdrawal 32 89.84 High High
anesthesia 9 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 201 98.40 Very High Very High Very High
Pancreatic Cancer 47 97.92 Very High Very High Very High
Hyperplasia 8 93.64 High High
Cancer 70 86.44 High High
Alzheimer's Dementia 1 80.00 Quite High
Adhesions 16 78.80 Quite High
Syndrome 3 73.64 Quite High
Dysplastic Nevus Syndrome 1 65.72 Quite High
Skin Cancer 8 63.72 Quite High
Pancreatitis 5 62.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, stable overexpression of TERT in cell culture, including human mammary epithelial cells, mouse ES cells, and MEFs also led to a specific transcriptional response [41–43].
Positive_regulation (overexpression) of Gene_expression (overexpression) of TERT in epithelial cells
1) Confidence 0.68 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0
Overall, TERT overexpression recapitulates the effects of Myc in enhancing proliferation of epidermal progenitor cells in the interfollicular skin, but does not cause the sebaceous gland hyperplasia seen with Myc overexpression (see Text S1 and Figure S5 for additional details).
Positive_regulation (overexpression) of Gene_expression (overexpression) of TERT in sebaceous gland associated with hyperplasia
2) Confidence 0.68 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0
In this tetracycline-off configuration, double transgenic K5-tTA+; tetop-TERT+ mice and K5-tTA+; tetop-TERTci+ mice were treated with doxycycline-drinking water throughout embryogenesis to suppress transgenic TERT expression, then switched to normal water between postnatal days 10–21 to induce TERT expression.
Positive_regulation (induce) of Gene_expression (expression) of TERT associated with targeted disruption
3) Confidence 0.68 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.65 Pain Relevance 0.03
Convergence of TERT, Myc, and Wnt Pathways
Positive_regulation (Convergence) of Gene_expression (Convergence) of TERT
4) Confidence 0.49 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0
The striking similarities between their gene expression programs and the fact that TERT expression phenocopies beta-catenin in skin suggest the possibility that TERT impinges upon the Wnt pathway (see Text S1 and Table S10 for additional details).
Positive_regulation (phenocopies) of Gene_expression (expression) of TERT in skin
5) Confidence 0.49 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0
In the TERT-off cohort, biopsies were obtained immediately before doxycycline treatment (t = 0), as well as 6, 12, and 24 hours after doxycycline injection to extinguish TERT expression.
Positive_regulation (extinguish) of Gene_expression (expression) of TERT
6) Confidence 0.49 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.03
These data indicate that the effects of TERT overexpression on skin extend beyond activation of bulge stem cells and include stimulation of progenitors in the basal layer of IFE.


Positive_regulation (overexpression) of Gene_expression (overexpression) of TERT in skin
7) Confidence 0.49 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.17 Pain Relevance 0.04
The similarities between the effects of these developmental regulators and those of conditional TERT overexpression suggest the possibility that TERT may act through one or more of these essential pathways.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TERT
8) Confidence 0.46 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0
Both mRNA and protein levels of telomerase reverse transcriptase (hTERT) are significantly elevated in pancreatic juice of almost 90% of patients with pancreatic carcinomas [28], [29].
Positive_regulation (elevated) of Gene_expression (levels) of hTERT associated with pancreatic cancer
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776527 Disease Relevance 1.17 Pain Relevance 0.07

General Comments

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