INT220783

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 39
Total Number 55
Disease Relevance 12.55
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) chromosome (Tert) RNA binding (Tert)
nucleus (Tert) DNA binding (Tert) nucleotidyltransferase activity (Tert)
Anatomy Link Frequency
skin 6
tongue 2
telomere 2
stem cells 2
embryos 1
Tert (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 51 96.16 Very High Very High Very High
withdrawal 120 89.84 High High
Serotonin 60 85.44 High High
Central nervous system 15 83.72 Quite High
sodium channel 165 82.04 Quite High
Nucleus accumbens 15 77.84 Quite High
Ventral tegmentum 15 70.04 Quite High
midbrain 15 68.00 Quite High
adenocard 15 59.04 Quite High
TRP channel 15 43.92 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 841 99.98 Very High Very High Very High
Cancer 399 98.92 Very High Very High Very High
Alopecia 1023 98.64 Very High Very High Very High
Aging 84 98.56 Very High Very High Very High
Suicidal Behaviour 3 98.14 Very High Very High Very High
Adhesions 75 97.24 Very High Very High Very High
Pancreatic Cancer 47 96.80 Very High Very High Very High
Immunotherapy Of Cancer 9 95.44 Very High Very High Very High
Congenital Anomalies 18 95.24 Very High Very High Very High
Hyperplasia 33 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myc causes depletion of BrdU from LRCs in the IFE, but unlike conditional expression of either TERT or beta-catenin, Myc has not been reported to initiate a new anagen cycle [53].
Gene_expression (expression) of TERT
1) Confidence 0.77 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.11 Pain Relevance 0
In the TERT-off cohort, biopsies were obtained immediately before doxycycline treatment (t = 0), as well as 6, 12, and 24 hours after doxycycline injection to extinguish TERT expression.
Gene_expression (expression) of TERT
2) Confidence 0.77 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.03
Thus, expression of TERT constitutes a signal that impinges on these gene clusters based on the cis-sequences in their promoter regions and/or their physical location in the nucleus.
Gene_expression (expression) of TERT in nucleus
3) Confidence 0.77 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0
TERT expression by Northern blot in the TERT-off cohort was efficiently suppressed by doxycycline injection within 6 hours (Figure 4B).
Gene_expression (expression) of TERT
4) Confidence 0.77 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.04
Overall, TERT overexpression recapitulates the effects of Myc in enhancing proliferation of epidermal progenitor cells in the interfollicular skin, but does not cause the sebaceous gland hyperplasia seen with Myc overexpression (see Text S1 and Figure S5 for additional details).
Gene_expression (overexpression) of TERT in sebaceous gland associated with hyperplasia
5) Confidence 0.77 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0
We obtained RNA from skin biopsies from double transgenic mice (hereafter referred to as iK5-TERT and iK5-TERTci) and analyzed TERT expression by Northern blot.
Spec (analyzed) Gene_expression (expression) of TERT in skin associated with targeted disruption
6) Confidence 0.77 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.66 Pain Relevance 0.04
In this tetracycline-off configuration, double transgenic K5-tTA+; tetop-TERT+ mice and K5-tTA+; tetop-TERTci+ mice were treated with doxycycline-drinking water throughout embryogenesis to suppress transgenic TERT expression, then switched to normal water between postnatal days 10–21 to induce TERT expression.
Gene_expression (expression) of TERT associated with targeted disruption
7) Confidence 0.77 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.65 Pain Relevance 0.03
Interestingly, stable overexpression of TERT in cell culture, including human mammary epithelial cells, mouse ES cells, and MEFs also led to a specific transcriptional response [41–43].
Gene_expression (overexpression) of TERT in epithelial cells
8) Confidence 0.77 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0
The striking similarities between their gene expression programs and the fact that TERT expression phenocopies beta-catenin in skin suggest the possibility that TERT impinges upon the Wnt pathway (see Text S1 and Table S10 for additional details).
Gene_expression (expression) of TERT in skin
9) Confidence 0.77 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0
These data indicate that the effects of TERT overexpression on skin extend beyond activation of bulge stem cells and include stimulation of progenitors in the basal layer of IFE.


Gene_expression (overexpression) of TERT in skin
10) Confidence 0.77 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.17 Pain Relevance 0.04
After induction of these changes, we then administered doxycycline to silence TERT expression, followed by a series of closely spaced serial biopsies.
Gene_expression (expression) of TERT
11) Confidence 0.67 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0.03
Importantly, the expression of nearly all TERT-regulated genes was altered within 6–12 hours, kinetics consistent with a primary role for TERT in altering gene expression.
Gene_expression (expression) of TERT-regulated
12) Confidence 0.67 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.03
In this tetracycline-off configuration, double transgenic K5-tTA+; tetop-TERT+ mice and K5-tTA+; tetop-TERTci+ mice were treated with doxycycline-drinking water throughout embryogenesis to suppress transgenic TERT expression, then switched to normal water between postnatal days 10–21 to induce TERT expression.
Gene_expression (expression) of TERT associated with targeted disruption
13) Confidence 0.67 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.63 Pain Relevance 0.03
This role depends on its ability to synthesize telomere repeats in a manner dependent on the reverse transcriptase (RT) function of its protein component telomerase RT (TERT), as well as on a novel pathway whose mechanism is poorly understood.
Gene_expression (function) of TERT in telomere
14) Confidence 0.66 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0
Convergence of TERT, Myc, and Wnt Pathways
Gene_expression (Convergence) of TERT
15) Confidence 0.66 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0
Importantly, the expression of nearly all TERT-regulated genes was altered within 6–12 hours, kinetics consistent with a primary role for TERT in altering gene expression.
Gene_expression (expression) of TERT
16) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.03
The similarities between the effects of these developmental regulators and those of conditional TERT overexpression suggest the possibility that TERT may act through one or more of these essential pathways.
Gene_expression (overexpression) of TERT
17) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0
Hierarchical clustering of these data revealed a total of 673 TERT-regulated genes; 418 genes were down-regulated in TERT-off samples (TERT-activated genes) and 255 genes were up-regulated in TERT-off samples (TERT-repressed genes) (Figure 4C).
Gene_expression (samples) of TERT-activated
18) Confidence 0.58 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.04
Hierarchical clustering of these data revealed a total of 673 TERT-regulated genes; 418 genes were down-regulated in TERT-off samples (TERT-activated genes) and 255 genes were up-regulated in TERT-off samples (TERT-repressed genes) (Figure 4C).
Gene_expression (samples) of TERT-off
19) Confidence 0.58 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.04
We noted that TERT-regulated genes were frequently members of multi-gene families whose transcriptional start sites are in close physical proximity.
Gene_expression (members) of TERT-regulated
20) Confidence 0.58 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.21 Pain Relevance 0.04

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