INT220785

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.90
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) chromosome (Tert) RNA binding (Tert)
nucleus (Tert) DNA binding (Tert) nucleotidyltransferase activity (Tert)
Anatomy Link Frequency
skin 3
hair 2
telomere 2
Tert (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 48 97.80 Very High Very High Very High
imagery 49 94.40 High High
anesthesia 14 54.40 Quite High
cytokine 21 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 316 99.50 Very High Very High Very High
Immunotherapy Of Cancer 3 98.36 Very High Very High Very High
Alopecia 409 98.20 Very High Very High Very High
Cancer 158 98.04 Very High Very High Very High
Pancreatic Cancer 47 97.92 Very High Very High Very High
Melanoma 22 97.12 Very High Very High Very High
Body Weight 24 93.48 High High
Hematological Disease 44 85.76 High High
Glioblastoma 5 82.36 Quite High
Alzheimer's Dementia 1 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that conditional upregulation of TERT in the K5 compartment of the hair follicle stimulates robust hair growth through a mechanism that does not require enzymatic function.
Positive_regulation (upregulation) of TERT in hair associated with alopecia
1) Confidence 0.68 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.84 Pain Relevance 0
Thus, TERT mRNA was efficiently induced in the skin of iK5-TERT and iK5-TERTci mice following withdrawal of doxycycline.
Positive_regulation (induced) of TERT mRNA in skin associated with withdrawal
2) Confidence 0.68 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.59 Pain Relevance 0.05
Conditional upregulation of TERT in skin initiates a premature anagen during this prolonged second telogen phase [3].
Positive_regulation (upregulation) of TERT in skin
3) Confidence 0.68 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.42 Pain Relevance 0.04
To determine if expression of wild-type TERT or TERTci in the K5 layer caused hair growth, doxycycline-drinking water was withdrawn from double transgenic mice at day 21 to allow TERT upregulation.
Positive_regulation (upregulation) of TERT in hair associated with targeted disruption and alopecia
4) Confidence 0.60 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.70 Pain Relevance 0
These data show that RT activity is not required for induction of anagen when TERT is conditionally upregulated in mouse skin.


Positive_regulation (upregulated) of TERT in skin
5) Confidence 0.60 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.51 Pain Relevance 0
Myc binding sites and TCF/LEF binding sites, the elements through which Wnt signaling is mediated, were over-represented among TERT-repressed and TERT-activated genes, respectively (Table S8).
Positive_regulation (represented) of TERT-activated
6) Confidence 0.49 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0
To avoid the dramatic tissue changes associated with activating TERT and inducing anagen, we instead used iK5-TERT mice in which we allowed TERT to first induce anagen and hyper-proliferation of IFE.
Positive_regulation (activating) of TERT
7) Confidence 0.49 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.07 Pain Relevance 0.03
Mice were then switched from doxycycline water to normal water to allow upregulation of the TERT transgene.
Positive_regulation (upregulation) of TERT
8) Confidence 0.46 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.22 Pain Relevance 0.05
Our results showing that TERT's catalytic function is not required for its ability to regulate epidermal progenitor cells indicate that TERT acts through novel mechanisms that do not require enzymatic action at telomere ends.
Neg (not) Positive_regulation (required) of TERT in telomere
9) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.13 Pain Relevance 0
Myc binding sites and TCF/LEF binding sites, the elements through which Wnt signaling is mediated, were over-represented among TERT-repressed and TERT-activated genes, respectively (Table S8).
Positive_regulation (represented) of TERT-repressed
10) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0
E-boxes did not show an increased frequency in TERT promoter elements, which may represent an issue with the degeneracy of the short E-box sequence and limitations in locating relevant sites through this scanning approach.
Neg (not) Positive_regulation (increased) of TERT
11) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.26 Pain Relevance 0
g/ml) was administered in drinking water throughout development until post-natal day 10–21 to continually suppress transgenic TERT expression during development and allow TERT upregulation to occur postnatally.
Positive_regulation (upregulation) of TERT associated with targeted disruption
12) Confidence 0.40 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.38 Pain Relevance 0
The NK activity-stimulating effect of rAAV-/rAdv-hTERTC27 represents a novel way to exploit the functions of TERT in cancer treatment. hTERTC27 contains two peptides, p973 and p988, both of which have been shown to induce TERT specific CTLs in vitro or in vivo to lyse TERT+ tumor cells, including melanoma B16 cells [38], [39].
Positive_regulation (induce) of TERT associated with melanoma, cancer and immunotherapy of cancer
13) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938346 Disease Relevance 1.11 Pain Relevance 0
Each of these domains is required for full activity [6], but the TR-binding and enzymatic RT domains of TERT are particularly critical for telomere maintenance [13].
Positive_regulation (required) of TR in telomere
14) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.45 Pain Relevance 0
Both mRNA and protein levels of telomerase reverse transcriptase (hTERT) are significantly elevated in pancreatic juice of almost 90% of patients with pancreatic carcinomas [28], [29].
Positive_regulation (elevated) of hTERT associated with pancreatic cancer
15) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776527 Disease Relevance 1.10 Pain Relevance 0.07

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