INT220786

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.55
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) chromosome (Tert) RNA binding (Tert)
nucleus (Tert) DNA binding (Tert) nucleotidyltransferase activity (Tert)
Anatomy Link Frequency
cardiomyocyte 1
hair follicle 1
skin 1
stem cell 1
Tert (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 28 58.88 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 138 98.44 Very High Very High Very High
Obesity 169 97.80 Very High Very High Very High
Alopecia 238 93.96 High High
Targeted Disruption 175 72.40 Quite High
Skin Abnormalities 7 60.44 Quite High
Stress 17 50.00 Quite Low
Cancer 37 35.36 Quite Low
Lifespan 13 28.72 Quite Low
Skin Cancer 8 20.68 Low Low
Colon Cancer 7 20.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine if TERT's RT activity is required to promote stem cell proliferation, we inactivated TERT RT function by introducing a point mutation in its active site.
Negative_regulation (inactivated) of TERT in stem cell
1) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0
Together, these data show that TERT down-regulation prompted a significant and acute gene expression change in mouse skin (Figure 4C and Table S3).
Negative_regulation (regulation) of TERT in skin
2) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.03
Thus, the Wnt and Myc signaling networks may adapt to minimize the loss of TERT during embryonic development, even though TERT is an active component of these networks in wild-type mice.
Negative_regulation (loss) of TERT
3) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.11 Pain Relevance 0
A number of TERT-activated genes were prominent members of the Wnt, Shh and BMP pathways, signaling cascades critical for hair follicle development and cycling.
Negative_regulation (number) of TERT-activated in hair follicle
4) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.14 Pain Relevance 0
This approach requires that we reduce our TERT-regulated gene data set to a rank-ordered list, which is then queried by each individual gene set in the curated database.
Negative_regulation (reduce) of TERT-regulated
5) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.20 Pain Relevance 0
Using this approach, we confirmed that TCF/LEF sites were highly enriched in TERT-activated genes, consistent with our preceding results (p < 0.05).
Negative_regulation (enriched) of TERT-activated
6) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.37 Pain Relevance 0
Similarly, in the anti-growth gene list, TERT-repressed genes were always well represented, whereas TERT-activated genes were seldom seen regardless of parameters used to define the TERT-regulated gene list (Figure 6E).
Negative_regulation (represented) of TERT-repressed
7) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.60 Pain Relevance 0
Consistent with our previous
                   report [22], pharmacological level of leptin (50 nM)
                   overtly impaired cardiomyocyte mechanical function including depressed PS and
                   ± dL/dt as well as prolonged TPS and TR90 in both young
                   and aging C57 or ob/ob mouse groups (Fig. 3A–3F). 
Negative_regulation (impaired) of TR90 in cardiomyocyte associated with aging and obesity
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.12 Pain Relevance 0

General Comments

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