INT220787

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 0.87
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) chromosome (Tert) RNA binding (Tert)
nucleus (Tert) DNA binding (Tert) nucleotidyltransferase activity (Tert)
Anatomy Link Frequency
vesicles 1
nucleus 1
Tert (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 16 99.98 Very High Very High Very High
adenocard 4 98.52 Very High Very High Very High
midbrain 4 87.44 High High
Ventral tegmentum 4 84.48 Quite High
Neuropeptide 4 76.96 Quite High
withdrawal 12 72.84 Quite High
Nucleus accumbens 4 68.48 Quite High
Central nervous system 4 57.12 Quite High
member 8 4 42.36 Quite Low
Action potential 12 18.32 Low Low
Disease Link Frequency Relevance Heat
Salivary Gland Disease 8 91.84 High High
Aids-related Complex 4 90.32 High High
Congenital Anomalies 6 86.16 High High
Targeted Disruption 102 79.76 Quite High
Anaemia 10 60.04 Quite High
Hematological Disease 44 36.72 Quite Low
Aging 10 7.84 Low Low
Alopecia 103 5.00 Very Low Very Low Very Low
Apoptosis 39 5.00 Very Low Very Low Very Low
Cancer 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data provide important justification for investigating the biochemistry and cell biology of TERT, areas that have remained largely refractory to analysis due to the very low abundance of TERT in cells and tissues.
Localization (abundance) of TERT
1) Confidence 0.69 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.16 Pain Relevance 0
These data provide important justification for investigating the biochemistry and cell biology of TERT, areas that have remained largely refractory to analysis due to the very low abundance of TERT in cells and tissues.
Localization (abundance) of TERT
2) Confidence 0.64 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.15 Pain Relevance 0
Unsupervised clustering of both samples and genes revealed that the t = 0 samples from TERT-off mice were more closely related to TERT-on mice, indicating that changes in TERT levels, rather than other variables, underlie these gene expression changes (Figure S4).
Localization (related) of TERT
3) Confidence 0.64 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0.04
Electron microscopy analyses of ghrelin in secretory vesicles, while revealing, would not provide conclusive evidence that ghrelin is actually secreted from the TCs during taste perception.
Localization (secreted) of TCs in vesicles
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.09 Pain Relevance 0
Future studies are needed that may definitely demonstrate that ghrelin (and other additional hormones expressed in TCs) is released from TCs.
Localization (released) of TCs
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.07 Pain Relevance 0.06
Current limitations in available technology to measure active, functional hormone release from TCs in response to tastants, need to be overcome to facilitate these measurements, as current methods all have significant logistical flaws.
Localization (release) of TCs
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0.05
-triphosphate (ATP) and serotonin secretion from the TCs [41].
Localization (secretion) of TCs associated with serotonin
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.09 Pain Relevance 0.35
TR-zTERT no longer specifically localizes in the nucleus (Figure 6B, d, d'), but still rescues the hematopoietic phenotype, the activities of ?
Localization (localizes) of TR in nucleus
8) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.22 Pain Relevance 0

General Comments

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