INT220790

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.07
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hair 3
keratinocyte 1
hl (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 16 79.52 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alopecia 136 100.00 Very High Very High Very High
Adhesions 8 90.36 High High
Targeted Disruption 100 49.24 Quite Low
Cancer 20 47.44 Quite Low
Injury 4 25.00 Low Low
Body Weight 8 5.00 Very Low Very Low Very Low
Aging 8 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Helminth Infection 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these data show that TERT promotes epithelial proliferation through an intrinsic developmental program that coordinates the expression of hair growth and anti–hair growth genes.


Gene_expression (expression) of hair in hair associated with alopecia
1) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.49 Pain Relevance 0
For example, TERT strongly activated expression of hair keratins, such as Krt31 through Krt36.
Gene_expression (expression) of hair in hair
2) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0.04
We show that TERTci retains the full activities of wild-type TERT in enhancing keratinocyte proliferation in skin and in activating resting hair follicle stem cells, which triggers initiation of a new hair follicle growth phase and promotes hair synthesis.
Gene_expression (synthesis) of hair in keratinocyte
3) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0
Together, these data show that TERT promotes epithelial proliferation through an intrinsic developmental program that coordinates the expression of hair growth and anti–hair growth genes.


Gene_expression (expression) of hair in hair associated with alopecia
4) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.49 Pain Relevance 0

General Comments

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