INT22080

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Context Info
Confidence 0.53
First Reported 1985
Last Reported 2011
Negated 8
Speculated 5
Reported most in Body
Documents 40
Total Number 45
Disease Relevance 36.24
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 4
blood 3
plasma 1
PSCs 1
brain 1
ras (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 6 99.48 Very High Very High Very High
imagery 10 98.56 Very High Very High Very High
beta blocker 11 98.20 Very High Very High Very High
Chronic pancreatitis 12 97.68 Very High Very High Very High
alcohol 4 97.44 Very High Very High Very High
bradykinin 9 97.36 Very High Very High Very High
Migraine 11 97.24 Very High Very High Very High
noradrenaline 1 96.88 Very High Very High Very High
Inflammation 107 96.80 Very High Very High Very High
Clonidine 8 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 485 100.00 Very High Very High Very High
Canker Sores 317 100.00 Very High Very High Very High
Hypertension 130 100.00 Very High Very High Very High
Post-traumatic Stress Disorder 20 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 6 100.00 Very High Very High Very High
Renal Artery Obstruction 3 100.00 Very High Very High Very High
Nicotine Addiction 311 99.84 Very High Very High Very High
Coronary Artery Disease 65 99.84 Very High Very High Very High
Stress 46 99.68 Very High Very High Very High
Left Ventricular Hypertrophy 10 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the method of tobacco use, cigarettes or narghile, had no significant effect on the AP of RAS.
Neg (no) Regulation (effect) of RAS associated with canker sores
1) Confidence 0.53 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 1.74 Pain Relevance 0
The prevalence of RAS was not significantly affected by history of tobacco use (Table 1).
Neg (not) Regulation (affected) of RAS associated with canker sores
2) Confidence 0.44 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 1.61 Pain Relevance 0
An awareness of literature suggesting etiologies, precipitating, and predisposing factors can assist the practitioner and patient in controlling RAS episodes.
Regulation (controlling) of RAS associated with canker sores
3) Confidence 0.43 Published 1996 Journal Nurse Pract Section Abstract Doc Link 8734624 Disease Relevance 1.03 Pain Relevance 0.13
The discovery that drugs influencing the renin-angiotensin system (RAS), which have few side-effects, were effective in some patients with migraine led to several studies investigating a possible link between the angiotensin system and migraine pathophysiology.
Regulation (influencing) of RAS associated with migraine
4) Confidence 0.41 Published 2006 Journal J Hypertens Suppl Section Abstract Doc Link 16601567 Disease Relevance 0.57 Pain Relevance 0.57
The effect of RAS blockade via ARBs also has significant effects on glucose metabolism.
Regulation (effect) of RAS
5) Confidence 0.38 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.56 Pain Relevance 0.05
The role of Ras mutation in pancreatic cancer, precancerous lesions, and chronic pancreatitis.
Regulation (role) of Ras associated with pancreatic cancer and chronic pancreatitis
6) Confidence 0.37 Published 1993 Journal Int. J. Pancreatol. Section Title Doc Link 8113625 Disease Relevance 1.40 Pain Relevance 0.26
Levels of plasma renin activity were unchanged in EH and RAS but progressively fell in RPD.
Neg (unchanged) Regulation (unchanged) of RAS in plasma associated with renal artery obstruction, hypertension and disease
7) Confidence 0.37 Published 1985 Journal J Hypertens Suppl Section Abstract Doc Link 3913757 Disease Relevance 1.33 Pain Relevance 0.45
In our previous clinical trial [11], we have demonstrated that amlexanox oral adhesive tablets (active component is 2 mg amlexanox) are effective in the treatment of RAS without major side effects recorded, which were consistent with the previous trials [8,9].
Regulation (effective) of RAS associated with canker sores
8) Confidence 0.31 Published 2009 Journal Trials Section Body Doc Link PMC2690593 Disease Relevance 0.83 Pain Relevance 0.08
METHODS: The effects of enalapril, losartan and their combination on blood pressure, renal haemodynamics, renal function and RAS were investigated over a wide range of doses in spontaneously hypertensive rats fed either a low-sodium or a high-sodium diet.
Spec (investigated) Regulation (effects) of RAS in blood
9) Confidence 0.27 Published 2004 Journal J. Hypertens. Section Body Doc Link 15076169 Disease Relevance 0 Pain Relevance 0
The present study investigates the voluntary modulation of RAS employing hypnosis-like relaxation/imagery training procedures.
Spec (investigates) Regulation (modulation) of RAS associated with imagery and canker sores
10) Confidence 0.27 Published 1990 Journal Psychosom Med Section Abstract Doc Link 2247558 Disease Relevance 1.13 Pain Relevance 0.21
The “protective effect” of tobacco on RAS was only noticed when persons were heavy smokers or smoked for longer periods of time.
Regulation (effect) of RAS associated with nicotine addiction and canker sores
11) Confidence 0.27 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 2.26 Pain Relevance 0.04
When lesions are present, smoking had no effect on RAS severity.



Neg (no) Regulation (effect) of RAS associated with nicotine addiction and canker sores
12) Confidence 0.27 Published 2010 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2999509 Disease Relevance 1.68 Pain Relevance 0
Ras activity within cells can also be modulated through the introduction of farnesyl-transferase inhibitors.
Regulation (modulated) of Ras
13) Confidence 0.26 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.58 Pain Relevance 0.23
Thus, direct renin inhibitors such as aliskerin hold further promise in elucidating the importance of the RAS in coronary atherosclerosis.
Regulation (importance) of RAS associated with coronary artery disease
14) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.42 Pain Relevance 0
This review addresses the history of the ras oncogene, the techniques used to detect molecular alterations in the ras oncogene, and the application of polymerase chain reaction (PCR)-based methods to determine point mutations in clinical samples of patients with pancreatic diseases, namely pancreatic carcinoma and chronic pancreatitis.
Regulation (alterations) of ras associated with pancreatic cancer, pancreatitis and chronic pancreatitis
15) Confidence 0.21 Published 2000 Journal Int. J. Pancreatol. Section Abstract Doc Link 10862508 Disease Relevance 0.51 Pain Relevance 0.16
The long-lasting consequences of prolonged prepubertal stress were similar in the two strains and were determined by the specificity of stress stimulation: chronic handling had no effect on the ASR, while CVS enhanced it.
Neg (no) Regulation (effect) of ASR associated with stress, post-traumatic stress disorder and sprains and strains
16) Confidence 0.21 Published 2002 Journal Physiol. Behav. Section Abstract Doc Link 11890971 Disease Relevance 2.07 Pain Relevance 0
The long-lasting effect of CVS experienced in prepubertal life appears to produce ASR changes similar to those seen in patients with posttraumatic stress disorder (PTSD).
Regulation (changes) of ASR associated with stress and post-traumatic stress disorder
17) Confidence 0.21 Published 2002 Journal Physiol. Behav. Section Abstract Doc Link 11890971 Disease Relevance 2.03 Pain Relevance 0
The combination of an antihypertensive agent that blocks the RAS with one that does not is likely to be a more effective approach than using two agents that both block the RAS (eg, ACE-I+ARB)21,22 or two agents that do not affect the RAS (eg, CCB+diuretic).
Neg (not) Regulation (affect) of RAS
18) Confidence 0.16 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2773747 Disease Relevance 0.23 Pain Relevance 0.04
Three pathways are critically involved in blood pressure regulation during anaesthesia, i.e. the sympathetic nervous system, the renin angiotensin system (RAS), and the vasopressinergic system.
Regulation (regulation) of RAS in sympathetic nervous system
19) Confidence 0.16 Published 2008 Journal Best Pract Res Clin Anaesthesiol Section Abstract Doc Link 18683482 Disease Relevance 0.07 Pain Relevance 0.21
The data presented here indicates that the tumor RAS may be differentially regulated from the adjacent liver RAS.
Spec (may) Regulation (regulated) of RAS in liver associated with cancer
20) Confidence 0.16 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.29 Pain Relevance 0

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