INT220802

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 14
Disease Relevance 3.86
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (LEF1) cell adhesion (LEF1) nucleus (LEF1)
DNA binding (LEF1) transcription factor binding (LEF1) cytoplasm (LEF1)
Anatomy Link Frequency
SW480 1
lymphocyte 1
LEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 8 87.52 High High
aspirin 56 5.00 Very Low Very Low Very Low
antagonist 44 5.00 Very Low Very Low Very Low
cINOD 24 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 304 99.84 Very High Very High Very High
Cancer 142 99.52 Very High Very High Very High
Colon Cancer 38 98.68 Very High Very High Very High
Hyperplasia 10 91.12 High High
Stress 28 89.84 High High
Apoptosis 114 86.80 High High
Malignant Neoplastic Disease 24 86.08 High High
Adenocarcinoma 8 85.84 High High
Adenoma 8 85.08 High High
Alopecia 68 64.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To independently validate these findings, we prospectively scanned the promoter regions of TERT-regulated genes using TRANSFAC consensus binding sequences for both Myc and TCF/LEF.
LEF Binding (binding) of
1) Confidence 0.36 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.17 Pain Relevance 0
E-boxes, the DNA motifs recognized by Myc/Max heterodimers, and TCF/LEF motifs, the sites through which beta-catenin acts, were enriched as conserved motifs in TERT-repressed genes and TERT-activated genes, respectively.
LEF Binding (recognized) of
2) Confidence 0.36 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.08 Pain Relevance 0
A direct interaction between Groucho and Lef1 occurs via a small region in the context regulatory domain (aa237-256) and a region in the highly conserved HMG DNA binding domain (aa296-396) [52].
Lef1 Binding (interaction) of
3) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.19 Pain Relevance 0
-catenin/Tcf/Lef complex
Lef Binding (complex) of
4) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
-catenin transcriptional activity by binding to Lef, forming a HDAC-Lef complex that hypoacetylates the promoter region of ?
Lef Binding (complex) of
5) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
-catenin on binding to the Tcf4/Lef1 complex and activating overexpression of Wnt target genes.

?

Lef1 Binding (complex) of
6) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.22 Pain Relevance 0
-catenin transcriptional activity by binding to Lef, forming a HDAC-Lef complex that hypoacetylates the promoter region of ?
Lef Binding (binding) of
7) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
-catenin/Tcf4/Lef1 complex
Lef1 Binding (complex) of
8) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.26 Pain Relevance 0
-catenin to bind to Lef and recover the transcriptional activity of the ?
Lef Binding (bind) of
9) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
-catenin accumulates in the cytoplasm and nucleus, where it interacts with coregulators of transcription including T cell factor/lymphocyte enhancer factor (Tcf/Lef) to form a ?
Lef Binding (interacts) of in lymphocyte
10) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.34 Pain Relevance 0
To test whether EA could similarly interact with LEF-1 in other tumor cells, a human colon cancer cell line SW480 was tested.
LEF Binding (interact) of in SW480 associated with cancer and colon cancer
11) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.53 Pain Relevance 0
To determine whether EA could indeed directly interact with LEF-1, CLL cells that had been treated with the drug were lysed, immunoprecipitated with anti-LEF-1 antibody, and probed in immunoblots using the anti-EA antibody (Figure 4A).
LEF Binding (interact) of associated with chronic lymphoid leukemia
12) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.56 Pain Relevance 0
-catenin signaling through directly interacting with LEF-1, one would expect that the drug should bind to LEF-1 in the LEF-1/?
LEF Binding (interacting) of
13) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.47 Pain Relevance 0
Here we demonstrate that EA can directly interact with LEF-1 protein in CLL cells, and destabilize the LEF-1/?
LEF-1 protein Binding (tly inte) of associated with chronic lymphoid leukemia
14) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 1.03 Pain Relevance 0.04

General Comments

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