INT22082

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Context Info
Confidence 0.80
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 2.44
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ceacam1) cell adhesion (Ceacam1) plasma membrane (Ceacam1)
Anatomy Link Frequency
osteoblasts 5
blood 1
nerve 1
osteocytes 1
superior cervical ganglion 1
Ceacam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 1 98.56 Very High Very High Very High
Neuropeptide 20 98.16 Very High Very High Very High
metalloproteinase 21 97.76 Very High Very High Very High
agonist 5 92.56 High High
adenocard 17 92.08 High High
Pain 13 90.56 High High
anesthesia 6 89.40 High High
halothane 1 88.96 High High
Sciatic nerve 2 84.92 Quite High
tetrodotoxin 2 79.92 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 23 99.84 Very High Very High Very High
Osteogenesis Imperfecta 25 98.74 Very High Very High Very High
Neuropathic Pain 1 98.56 Very High Very High Very High
Ganglion Cysts 6 98.36 Very High Very High Very High
Hypocalcemia 1 97.00 Very High Very High Very High
Nociception 12 94.92 High High
Pain 8 90.56 High High
Fatigue 1 75.32 Quite High
Fever 3 74.44 Quite High
Endometriosis (extended) 1 73.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteocalcin, the most abundant non-collagenous protein in the bone matrix, is partly released in blood.
Localization (released) of Osteocalcin in blood
1) Confidence 0.80 Published 1990 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 2247770 Disease Relevance 0.07 Pain Relevance 0
To confirm that the isolated cells were osteoblasts, the secretion of osteocalcin, a protein specifically secreted by osteoblast, into the culture medium was quantitated.
Localization (secreted) of osteocalcin in osteoblasts associated with osteoporosis
2) Confidence 0.70 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782207 Disease Relevance 0.15 Pain Relevance 0.10
To confirm that the isolated cells were osteoblasts, the secretion of osteocalcin, a protein specifically secreted by osteoblast, into the culture medium was quantitated.
Localization (secretion) of osteocalcin in osteoblasts associated with osteoporosis
3) Confidence 0.70 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782207 Disease Relevance 0.10 Pain Relevance 0.10
The mRNA transcripts of type I collagen and osteocalcin were localized in osteoblasts and osteocytes, some of which expressed MMPs 2, 8, and 13.
Localization (localized) of osteocalcin in osteocytes associated with metalloproteinase
4) Confidence 0.54 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.36
Quantitative analysis and localization of mRNA transcripts of type I collagen, osteocalcin, MMP 2, MMP 8, and MMP 13 during bone healing in a rat calvarial experimental defect model.
Localization (localization) of osteocalcin
5) Confidence 0.51 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Title Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.31
Neither NPB nor NPW changed osteocalcin secretion by cultured osteoblast-like cells while both neuropeptides inhibited their proliferative activity.
Localization (secretion) of osteocalcin in osteoblast associated with neuropeptide and osteoporosis
6) Confidence 0.47 Published 2009 Journal Int. J. Mol. Med. Section Abstract Doc Link 19885618 Disease Relevance 0.32 Pain Relevance 0.28
The present study aimed to investigate the expression of NPB, NPW, NPBWR1 and the similar to NPBWR2 genes in cultured rat calvarial osteoblast-like (ROB) cells and the effects of both peptides on proliferative activity and osteocalcin secretion by ROB cells.
Localization (secretion) of osteocalcin in osteoblast associated with osteoporosis
7) Confidence 0.47 Published 2009 Journal Int. J. Mol. Med. Section Abstract Doc Link 19885618 Disease Relevance 0.32 Pain Relevance 0.35
To our knowledge, the importance of ecto-nucleotidases for the kinetics of ATP release induced by nerve compression has not been studied before.
Localization (importance) of ecto-nucleotidases in nerve
8) Confidence 0.45 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096649 Disease Relevance 0.19 Pain Relevance 0.27
Urinary hydroxyproline excretion, serum osteocalcin, and alkaline phosphatase activity were higher in OPX and O/P rats compared with control animals at 3 weeks postoperation (OHPE microM GF, mean +/- SEM: sham 1.37 +/- 0.16, OPX 2.16 +/- 0.26, PTX 0.95 +/- 0.21, O/P 1.92 +/- 0.22, p < 0.005; osteocalcin, microgram/liter, sham 31.8 +/- 1.8, OPX 33.7 +/- 2.7, PTX 24.5 +/- 2.1, O/P 34.3 +/- 2.1, p < 0.025; alkaline phosphatase, U/liter, sham 90 +/- 3, OPX 125 +/- 9, PTX 87 +/- 9, O/P 116 +/- 11, p < 0.005).
Localization (excretion) of osteocalcin
9) Confidence 0.40 Published 1994 Journal J. Bone Miner. Res. Section Abstract Doc Link 7872050 Disease Relevance 0.07 Pain Relevance 0.13
This ecto-ATPases has been shown to be releasable into the surrounding media and the soluble form from Tetrahymena has been purified and characterized [50].
Localization (releasable) of ecto-ATPases
10) Confidence 0.26 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.09
The mRNA transcripts of type I collagen and osteocalcin were localized in osteoblasts and osteocytes, some of which expressed MMPs 2, 8, and 13.
Localization (localized) of osteocalcin in osteoblasts associated with metalloproteinase
11) Confidence 0.18 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.36
In addition, by using electron microscopic enzyme histochemistry, the presence of ectoATPase was also shown in the superior cervical ganglion.
Localization (presence) of ectoATPase in superior cervical ganglion associated with ganglion cysts
12) Confidence 0.18 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219952 Disease Relevance 0.34 Pain Relevance 0.14
The observed rise in serum osteocalcin concentration and urinary hydroxyproline excretion during the 2nd year of treatment with SCT was accompanied by a significant rise in serum calcitonin levels (P < 0.001 after 18 months and P < 0.01 after 24 months).
Localization (excretion) of osteocalcin
13) Confidence 0.11 Published 1997 Journal Maturitas Section Body Doc Link 9522322 Disease Relevance 0 Pain Relevance 0
The OI patients showed reduced levels of serum alkaline phosphatase, osteocalcin, and urinary excretion of calcium, which are suggestive of slowed bone turnover (6, 9, 11).
Localization (excretion) of osteocalcin associated with osteogenesis imperfecta
14) Confidence 0.06 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693583 Disease Relevance 0.88 Pain Relevance 0

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