INT220836

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.62
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
blood 1
lungs 1
T-cells 1
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 55 90.56 High High
rheumatoid arthritis 29 70.56 Quite High
Central nervous system 2 20.80 Low Low
cytokine 8 18.56 Low Low
Spinal cord 10 12.64 Low Low
corticosteroid 4 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iritis 1 100.00 Very High Very High Very High
Sprains And Strains 40 98.32 Very High Very High Very High
Cancer 69 98.12 Very High Very High Very High
Apoptosis 2 95.76 Very High Very High Very High
Pleurisy 1 92.96 High High
Lymphatic System Cancer 44 91.92 High High
Leukemia 23 91.52 High High
Ganglion Cysts 58 89.60 High High
Disease 32 88.36 High High
Immunization 11 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One patient, rheumatoid factor-positive and HLA-B27-positive, with iritis had no CD4+CD28null T cells either in blood or the synovial fluid.
Transcription (positive) of CD4 in blood associated with iritis
1) Confidence 0.61 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212553 Disease Relevance 0.67 Pain Relevance 0.04
Although the distributions of the CD4 and CD8 markers were rather stochastic in the tumor cells analyzed, we did find that single positive T–cells were usually skewed towards the CD8+ rather than to the CD4+ lineage.
Transcription (distributions) of CD4 in T-cells associated with cancer
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.13 Pain Relevance 0
In particular, transcriptional regulation of CD4 silencer and Th-POK have been described in detail [13,15].
Transcription (transcriptional) of CD4
3) Confidence 0.39 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.02 Pain Relevance 0.15
Furthermore, high levels of HA-specific CD4 and CD8 T-cells were detected in the lungs of mice immunized with the MVA-HA vaccine construct at the time of challenge with wild type H1N1/CA virus, with a further accumulation of effector T-cells observed in the lungs three days after the challenge.
Transcription (detected) of CD4 in lungs
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.79 Pain Relevance 0

General Comments

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