INT220857

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp14) cytoplasm (Mmp14)
Mmp14 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 64 92.56 High High
Osteoarthritis 19 89.20 High High
rheumatoid arthritis 38 52.76 Quite High
Arthritis 5 42.96 Quite Low
cva 1 35.08 Quite Low
cytokine 14 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 1 98.84 Very High Very High Very High
Fibrosarcoma 2 98.72 Very High Very High Very High
Skin Cancer 1 96.32 Very High Very High Very High
Osteoarthritis 19 89.20 High High
Disease 15 84.00 Quite High
Malignant Neoplastic Disease 1 83.64 Quite High
Cancer 8 80.72 Quite High
Congenital Anomalies 1 76.96 Quite High
Bone Cancer 1 57.84 Quite High
Rheumatoid Arthritis 38 52.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clodronate also inhibited the expression of the MT1-MMP protein and mRNA in the HT1080 fibrosarcoma cell line, and decreased the invasion of C8161 melanoma and HT1080 fibrosarcoma cell lines [73].


Negative_regulation (inhibited) of Transcription (expression) of MT1-MMP associated with fibrosarcoma and skin cancer
1) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 1.04 Pain Relevance 0.20

General Comments

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