INT220858

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 9.11
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) extracellular region (Mmp1a) proteinaceous extracellular matrix (Mmp1a)
Anatomy Link Frequency
placentas 2
sputum 1
synovial fluid 1
astrocytes 1
uterine 1
Mmp1a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 337 100.00 Very High Very High Very High
Arthritis 40 99.58 Very High Very High Very High
Inflammation 278 99.48 Very High Very High Very High
ischemia 11 98.32 Very High Very High Very High
rheumatoid arthritis 68 97.84 Very High Very High Very High
fibrosis 86 97.28 Very High Very High Very High
antagonist 109 96.44 Very High Very High Very High
Kinase C 10 95.12 Very High Very High Very High
cytokine 110 83.36 Quite High
Inflammatory response 46 83.04 Quite High
Disease Link Frequency Relevance Heat
Arthritis 42 99.58 Very High Very High Very High
INFLAMMATION 321 99.48 Very High Very High Very High
Premature Birth 400 99.16 Very High Very High Very High
Infection 350 99.10 Very High Very High Very High
Pulmonary Disease 147 98.64 Very High Very High Very High
Cv Unclassified Under Development 11 98.32 Very High Very High Very High
Pre-term Labor 130 97.88 Very High Very High Very High
Rheumatoid Arthritis 73 97.84 Very High Very High Very High
Reperfusion Injury 11 97.80 Very High Very High Very High
Emphysema 22 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
McolB is apparently devoid of collagenolytic activity.18 Thus, we cannot exclude the possibility that the missing effect of the MMP-13 inhibitor in the AIA model is due to the induction of MMP-1 in a highly inflammatory milieu.
Positive_regulation (induction) of MMP-1 associated with inflammation and arthritis
1) Confidence 0.38 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.51 Pain Relevance 0.24
Human recombinant activated MMP-1 (collagenase) and MMP-2 (gelatinase) were used as positive controls.
Positive_regulation (activated) of MMP-1
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0 Pain Relevance 0
Interestingly, Fujimoto et al. found that a polymorphism resulting in increased MMP-1 promoter activity resulted in an increased risk of preterm premature rupture of the membranes [44].
Positive_regulation (resulting) of MMP-1 associated with rupture
3) Confidence 0.16 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.54 Pain Relevance 0.13
We have shown that MMP-1 is upregulated in placental and uterine tissues of mice induced to preterm labor and delivery with LPS (manuscript submitted for publication) and that the MMP inhibitor GM6001 controls preterm birth in these same animal models.
Positive_regulation (upregulated) of MMP-1 in uterine associated with premature birth and pre-term labor
4) Confidence 0.16 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.90 Pain Relevance 0.29
Additionally, preterm PROM was associated with a significant increase in the median concentrations of amniotic MMP-1 in both the presence and absence of infection, while term PROM was not associated with an increase in MMP-1 levels [38].
Positive_regulation (increase) of MMP-1 associated with infection
5) Confidence 0.16 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.51 Pain Relevance 0.17
Interestingly, the upregulation in MMP-1 was seen in the fetal portion of the placenta, suggesting that the fetus can contribute to its own premature expulsion from a hostile intrauterine environment.
Positive_regulation (upregulation) of MMP-1 in placenta
6) Confidence 0.14 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.58 Pain Relevance 0
We were interested to find that knocking down ET-1 synthesis knocked down MMP-1 upregulation as well.
Positive_regulation (upregulation) of MMP-1
7) Confidence 0.14 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.77 Pain Relevance 0.19
Additionally, preterm PROM was associated with a significant increase in the median concentrations of amniotic MMP-1 in both the presence and absence of infection, while term PROM was not associated with an increase in MMP-1 levels [38].
Positive_regulation (increase) of MMP-1 associated with infection
8) Confidence 0.14 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.50 Pain Relevance 0.13
PDE4 inhibitor cilomilast was also shown to suppress the release and activation of MMP-1 and MMP-9 from lung fibroblasts, which are known to be involved in PF progression [18].
Positive_regulation (activation) of MMP-1 in fibroblasts associated with fibrosis
9) Confidence 0.12 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.71 Pain Relevance 0.24
In ET-1-activated human optic nerve head astrocytes, levels of MMP-1, TIMP-1, and TIMP-2 are all increased.
Positive_regulation (increased) of MMP-1 in astrocytes
10) Confidence 0.11 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.55 Pain Relevance 0.20
In particular, we found that MMP-1 was consistently elevated in placentas from patients who had labored as compared to placentas from patients who had not labored at both the mRNA and protein level.
Positive_regulation (elevated) of MMP-1 in placentas
11) Confidence 0.11 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.55 Pain Relevance 0
Interestingly, Fujimoto et al. found that a polymorphism resulting in increased MMP-1 promoter activity resulted in an increased risk of preterm premature rupture of the membranes [44].
Positive_regulation (increased) of MMP-1 associated with rupture
12) Confidence 0.11 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.54 Pain Relevance 0.13
Finally, Deschamps et al. [79] showed that the increase in MMP-1 levels in porcine hearts associated with ischemia and reperfusion injury did not occur if the animals were treated with the ET-1 receptor-A antagonist BQ-123.

6.

Positive_regulation (increase) of MMP-1 in hearts associated with reperfusion injury, antagonist and ischemia
13) Confidence 0.09 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.91 Pain Relevance 0.36
Several studies reported enhanced levels or gene mutations of MMPs like MMP-1, MMP-9 or MMP-12 associated with COPD and lung function decline (Joos et al 2002; Culpitt et al 2005; Demedts et al 2006), the presence of fragments of ECM proteins like elastin or collagen (Dillon et al 1992; Stone et al 1995; Weathington et al 2006), and/or altered levels of ECM molecules in sputum, BAL fluid or lung tissue of patients with COPD (Lang et al 1994; Dentener et al 2005; Kranenburg et al 2006; Martin-Mosquero et al 2006).
Positive_regulation (enhanced) of MMP-1 in sputum associated with pulmonary disease and metalloproteinase
14) Confidence 0.05 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.78 Pain Relevance 0.29
High levels of MMP-1, MMP-3, MMP-8 and MMP-9 are found in the synovial fluid of patients with RA [50].
Positive_regulation (levels) of MMP-1 in synovial fluid associated with rheumatoid arthritis
15) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.76 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox