INT220861

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 12.21
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp8) extracellular space (Mmp8) extracellular region (Mmp8)
proteinaceous extracellular matrix (Mmp8)
Anatomy Link Frequency
lung 5
synovial fluid 1
leukocytes 1
livers 1
amniotic fluid 1
Mmp8 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 665 100.00 Very High Very High Very High
rheumatoid arthritis 39 97.84 Very High Very High Very High
fibrosis 174 96.64 Very High Very High Very High
Mechanotransduction 4 91.56 High High
Inflammation 232 90.80 High High
Inflammatory response 40 82.56 Quite High
cytokine 103 66.48 Quite High
Arthritis 5 18.12 Low Low
Osteoarthritis 19 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 216 99.84 Very High Very High Very High
Bronchiolitis Obliterans 3 99.56 Very High Very High Very High
Mycobacterial Infection 145 99.32 Very High Very High Very High
Fibrosis 158 99.28 Very High Very High Very High
Targeted Disruption 47 99.14 Very High Very High Very High
Lung Injury 138 99.12 Very High Very High Very High
Autoimmune Disease 22 98.58 Very High Very High Very High
Pulmonary Disease 15 98.44 Very High Very High Very High
Bacterial Infection 23 98.32 Very High Very High Very High
Respiratory Distress 2 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiments without MMP-8 or adding TIMP-1 to the incubation buffer were conducted in parallel.
Positive_regulation (Experiments) of MMP-8
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.06 Pain Relevance 0.06
There were no differences in total collagenolytic activity between wildtype and knockout mice, thus discarding an overcompensatory increase of other collagenolytic enzymes in Mmp8?
Positive_regulation (increase) of Mmp8 associated with targeted disruption
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.76 Pain Relevance 0.16
Winkler et al. found elevated MMP8 levels in endotracheal aspirate of children with respiratory distress [46].
Positive_regulation (elevated) of MMP8 in respiratory associated with respiratory distress
3) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.92 Pain Relevance 0.11
Our results suggest that strategies to modulate MAPK and/or MMP8 activation may have potential therapeutic benefit in patients suffering from ventilator-associated lung injury/ARDS.


Positive_regulation (activation) of MMP8 in lung associated with lung injury and adult respiratory distress syndrome
4) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.95 Pain Relevance 0.09
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Positive_regulation (upregulated) of MMP-8 associated with fibrosis
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
Segura-Valdez et al. have found increased levels of MMP-8 and MMP-9 in Mini-BAL and lung biopsies of COPD patients [25].
Positive_regulation (increased) of MMP-8 in lung associated with pulmonary disease and metalloproteinase
6) Confidence 0.19 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.21 Pain Relevance 0.97
Hepatic transcript levels of MMP-8 (Figure 6C) and MMP-9 (Figure 6D) were 5.6-fold and 6.6-fold increased, respectively, in livers from Marimastat treated animals, whereas hepatic MMP-13 transcripts were 3.0-fold higher in the vehicle treated animals (Figure 6E).
Positive_regulation (increased) of MMP-8 in livers
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.23 Pain Relevance 0.03
The role of increased MMP-8 and MMP-9 concentrations and activity in bacterial infection of the lung is, in contrast to chronic disease, under debate.
Positive_regulation (increased) of MMP-8 in lung associated with metalloproteinase, bacterial infection and chronic disease
8) Confidence 0.17 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.45 Pain Relevance 0.88
Taghavi and coworkers have described increased MMP-9 and MMP-8 levels in bronchiolitis obliterans from lung transplant patients [28].
Positive_regulation (increased) of MMP-8 in lung associated with bronchiolitis obliterans and metalloproteinase
9) Confidence 0.13 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.45 Pain Relevance 0.95
Additional matrix metalloproteases, such as MMP9 and MMP8, were however not significantly induced at D21 in the M.tuberculosis-infected lungs (Table 2), although transcripts for MMP9 was induced early at D12.
Positive_regulation (induced) of MMP8 in lungs associated with mycobacterial infection and infection
10) Confidence 0.12 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.49 Pain Relevance 0.17
An increase in midtrimester concentrations of amniotic fluid MMP-8, IL-6, and angiogenin are risk factors for early spontaneous preterm delivery (<32 weeks).
Positive_regulation (increase) of MMP-8 in amniotic fluid associated with premature birth
11) Confidence 0.10 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.58 Pain Relevance 0.16
In terms of autoimmune disease several metalloproteinases including ADAM-17, MMP-9, MMP-3, MMP-2, or MMP-8 are reportedly increased in the serum or peripheral leukocytes of patients with systemic sclerosis, system lupus erythematosus, and Wegener's granulomatosis [106–109].
Positive_regulation (increased) of MMP-8 in leukocytes associated with autoimmune disease, metalloproteinase, systemic lupus erythematosus and systemic sclerosis
12) Confidence 0.09 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.36 Pain Relevance 0.52
In particular, an elevated MMP-8 level of >23?
Positive_regulation (elevated) of MMP-8
13) Confidence 0.08 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.67 Pain Relevance 0.04
High levels of MMP-1, MMP-3, MMP-8 and MMP-9 are found in the synovial fluid of patients with RA [50].
Positive_regulation (levels) of MMP-8 in synovial fluid associated with rheumatoid arthritis
14) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.76 Pain Relevance 0.41

General Comments

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