INT220862

Context Info Confidence 0.05 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.41 Pain Relevance 0.21

peptidase activity (Ctsl) histone binding (Ctsl) nucleolus (Ctsl) vacuole (Ctsl) lysosome (Ctsl) cytoplasm (Ctsl)

Ctsl (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 38 85.84 Arthritis 5 63.96 metalloproteinase 64 40.64 cytokine 14 28.32 Osteoarthritis 19 22.72 Inflammation 8 5.00 Neuropeptide 2 5.00 methotrexate 1 5.00 Pain 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 38 85.84 Arthritis 6 63.96 Congenital Anomalies 1 47.12 Disease 15 46.16 Fibrosarcoma 2 40.04 Skin Cancer 1 39.08 Reprotox - General 1 1 32.36 Osteoarthritis 19 22.72 Malignant Neoplastic Disease 1 17.16 Cancer 8 14.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this regard, inhibition of cathepsin L by a specific ribozyme was able to reduce expression of cathepsin L mRNA to 44% [84].

Negative_regulation (reduce) of Transcription (expression) of cathepsin L

1) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.41 Pain Relevance 0.21

General Comments

This test has worked.