INT22087

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.45
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DBH) extracellular region (DBH) cellular nitrogen compound metabolic process (DBH)
cytoplasm (DBH)
Anatomy Link Frequency
heart 1
DBH (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 28 100.00 Very High Very High Very High
noradrenaline 37 99.76 Very High Very High Very High
Neuropeptide 2 99.36 Very High Very High Very High
Clonidine 4 99.16 Very High Very High Very High
Locus ceruleus 6 96.72 Very High Very High Very High
antagonist 2 96.66 Very High Very High Very High
agonist 3 95.70 Very High Very High Very High
Hippocampus 1 86.08 High High
tolerance 4 64.20 Quite High
Central nervous system 3 64.20 Quite High
Disease Link Frequency Relevance Heat
Disease 8 99.24 Very High Very High Very High
Orthostatic Intolerance /

Orthostatic Intolerance

2 98.76 Very High Very High Very High
Myocardial Infarction 7 96.56 Very High Very High Very High
Pressure Volume 2 Under Development 24 83.52 Quite High
Muscle Hypotonia 4 79.20 Quite High
Hypothermia 6 78.48 Quite High
Hypoglycemia 8 77.84 Quite High
Congenital Anomalies 5 76.04 Quite High
Syncope 8 72.40 Quite High
Blepharoptosis 4 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following on the demonstrable benefit of beta-adrenergic blockade in heart failure, additional antiadrenergic measures (central suppression of sympathetic outflow with imidazoline binding agents such as clonidine, blocking of norepinephrine synthesis by dopamine-beta-hydroxylase inhibition, antagonism of neuropeptide Y) are now under active investigation.
Negative_regulation (inhibition) of dopamine-beta-hydroxylase in heart associated with dopamine, neuropeptide, myocardial infarction and clonidine
1) Confidence 0.59 Published 2000 Journal Heart Fail Rev Section Abstract Doc Link 16228913 Disease Relevance 0.37 Pain Relevance 0.27
Characterization of this procedure with the alpha 2-adrenoceptor antagonist, idazoxan, the corresponding agonist, clonidine, the alpha 1-adrenoceptor antagonist prazosine, and haloperidol, suggested that--DOPAC changes are more suitable than those of DA or DOPAC/DA ratios in reflecting changes in noradrenaline (NA) turnover, inhibiting DBH is advantageous if NA turnover is to be measured in projection areas, but not in LC, and haloperidol and prazosine, in principle, did not affect NA turnover.
Negative_regulation (inhibiting) of DBH associated with dopamine, locus ceruleus, antagonist, noradrenaline, agonist and clonidine
2) Confidence 0.42 Published 1990 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 2248732 Disease Relevance 0 Pain Relevance 1.04
Dopamine beta-hydroxylase deficiency
Negative_regulation (deficiency) of Dopamine beta-hydroxylase associated with dopamine
3) Confidence 0.39 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1459119 Disease Relevance 0.17 Pain Relevance 0.28
Dopamine beta-hydroxylase deficiency

Dopamine beta-hydroxylase (D?

Negative_regulation (deficiency) of Dopamine beta-hydroxylase associated with dopamine
4) Confidence 0.39 Published 2006 Journal Orphanet J Rare Dis Section Title Doc Link PMC1459119 Disease Relevance 0.81 Pain Relevance 0.25

General Comments

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