INT220886

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.04
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
liver 1
skin 1
kidney 1
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 63 98.60 Very High Very High Very High
Inflammation 12 79.52 Quite High
cytokine 12 28.36 Quite Low
fibrosis 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Dysuria 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 9 97.32 Very High Very High Very High
Systemic Lupus Erythematosus 18 94.00 High High
Disease Progression 1 93.72 High High
Hypersensitivity 2 87.28 High High
Targeted Disruption 10 84.68 Quite High
INFLAMMATION 12 79.52 Quite High
Acute-phase Reaction 1 66.08 Quite High
Disease 16 64.72 Quite High
Renal Disease 11 60.48 Quite High
Alzheimer's Dementia 1 32.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An up-regulation of C3 has been noted in the transplanted rat liver following induction of tolerance 28.
Regulation (regulation) of C3 in liver associated with tolerance
1) Confidence 0.36 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.09 Pain Relevance 0.19
Similarly, an unregulated C3 convertase could generate more C3 for opsonization and clearance of immune complexes, thus limiting accumulation of these complexes in the kidney and other organs.
Regulation (unregulated) of C3 in kidney
2) Confidence 0.30 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.91 Pain Relevance 0.07
We found a relative up-regulation of C1q and C3 in the male skin grafts in the tolerized recipients compared with the female grafts.
Regulation (regulation) of C3 in skin
3) Confidence 0.21 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.05 Pain Relevance 0.17

General Comments

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