INT220888

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.19
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Arhgap4) nucleus (Arhgap4) cytoplasm (Arhgap4)
Anatomy Link Frequency
CII 1
Arhgap4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dysuria 1 100.00 Very High Very High Very High
methotrexate 41 96.84 Very High Very High Very High
cytokine 15 89.88 High High
agonist 13 84.64 Quite High
nMDA receptor 129 83.96 Quite High
Inflammation 42 82.24 Quite High
rheumatoid arthritis 19 77.20 Quite High
Arthritis 69 65.68 Quite High
Hippocampus 69 56.48 Quite High
cerebral cortex 12 55.12 Quite High
Disease Link Frequency Relevance Heat
Edema 2 100.00 Very High Very High Very High
Ulcers 1 100.00 Very High Very High Very High
Exanthema 1 100.00 Very High Very High Very High
Sunburn 1 100.00 Very High Very High Very High
Aging 114 96.64 Very High Very High Very High
Increased Venous Pressure Under Development 6 94.72 High High
Systemic Lupus Erythematosus 23 93.16 High High
Disease 63 83.84 Quite High
INFLAMMATION 45 82.24 Quite High
Apoptosis 15 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-CII antibody levels in sera from rats treated with combination therapy were markly decreased, as were levels of IgG1, IgG2a, IgG2b and IgM.
Negative_regulation (decreased) of CII in CII
1) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.55 Pain Relevance 0.28
The patient presented at age 33 years with recurrent oral and genital ulcers, angioedema, malar rash, photosensitivity, dysuria, undetectable antinuclear antibodies, and normal C1 inhibitor levels.
Negative_regulation (presented) of C1 associated with exanthema, sunburn, dysuria, ulcers and edema
2) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.89 Pain Relevance 0.14
Its effects include binding to and subsequent inactivation of C1, inhibition of MAC assembly, and blockage of the formation of C3 convertase (Baker et al 1975; Hughes-Jones and Gardner 1978; Almeda et al 1983; Weiler 1983).
Negative_regulation (inactivation) of C1
3) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0 Pain Relevance 0
In the classical pathway, one of the main complement regulatory proteins is C1 inhibitor (C1-INH), which binds to the C1r:C1s complex and causes it to dissociate from C1q, thus preventing activation of the complement system.
Negative_regulation (inhibitor) of C1
4) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.30 Pain Relevance 0.11
The enhancement of the splice variants with the N terminal cassette spliced out and the loss of the C1 cassette mRNA and C2 cassette protein seem to be the most prominent changes during aging in the GluN1 subunit.
Negative_regulation (loss) of C1 associated with aging
5) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.45 Pain Relevance 0.24

General Comments

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