INT220890

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4b) extracellular region (C4b)
Anatomy Link Frequency
cleavage 1
nucleus 1
C4b (Mus musculus)
Pain Link Frequency Relevance Heat
unmyelinated 2 78.88 Quite High
nav1.8 1 63.60 Quite High
c fibre 1 63.04 Quite High
Central nervous system 1 52.20 Quite High
Peripheral nervous system 2 48.28 Quite Low
Demyelination 6 45.60 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
dorsal root ganglion 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 11 76.68 Quite High
Apoptosis 9 68.12 Quite High
Disease 14 67.84 Quite High
Renal Disease 9 64.40 Quite High
Sprains And Strains 7 53.44 Quite High
Demyelinating Disease 7 45.60 Quite Low
Injury 18 43.04 Quite Low
Systemic Lupus Erythematosus 16 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Fibrosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C4bp may be required for optimal cell recruitment, perhaps due to binding of a chemotactic product of C4b cleavage.
Localization (cleavage) of C4b in cleavage
1) Confidence 0.64 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.46 Pain Relevance 0
This activates the phosphatase calcineurin, which dephosphorylates nuclear factor of activated T cells (NFAT) c3 and c4, resulting in translocation to the nucleus.
Localization (translocation) of c4 in nucleus
2) Confidence 0.19 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.22

General Comments

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