INT220894

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.75
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3ar1) plasma membrane (C3ar1) signal transducer activity (C3ar1)
Anatomy Link Frequency
T-cells 1
C3ar1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 17 99.28 Very High Very High Very High
cytokine 25 88.32 High High
depression 1 83.08 Quite High
Inflammatory response 5 79.32 Quite High
Inflammation 23 61.60 Quite High
Arthritis 1 57.20 Quite High
ischemia 24 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
tissue acidosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 98 99.50 Very High Very High Very High
Cv General 3 Under Development 16 99.28 Very High Very High Very High
Sepsis 16 98.84 Very High Very High Very High
Obesity 2 95.04 Very High Very High Very High
Adhesions 6 92.88 High High
Coronary Artery Disease 32 88.52 High High
Disease 52 87.40 High High
Hypersensitivity 1 85.52 High High
Edema 2 85.12 High High
Shock 4 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All three pathways activate C3 by forming an enzyme, the C3 convertase, which cleaves C3 generating the C3a anaphylatoxin and the activation product C3b.
Positive_regulation (generating) of C3a
1) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.90 Pain Relevance 0.11
Following antigenic stimulation both DCs and T-cells upregulate C3a and C5a receptors, produce C3, alternative complement factors B and D, and downregulate CD55.
Positive_regulation (upregulate) of C3a in T-cells
2) Confidence 0.03 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.53 Pain Relevance 0.11
C3 levels were shown to be a strong predictor of MI, especially in men, and C3a levels were elevated in patients with unstable angina as compared to those with stable angina (Muscari et al 1995; Kostner et al 2006).
Positive_regulation (elevated) of C3a associated with cva and myocardial infarction
3) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.65 Pain Relevance 0.18
There are several studies reporting an increase in complement activation products (C5a, C3a, C5b-9) in animal models of sepsis, as well as in patients with sepsis and multiorgan system failure (Ward 2008).
Positive_regulation (increase) of C3a associated with sepsis
4) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.66 Pain Relevance 0

General Comments

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