INT220895

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 84.44 Quite High
depression 2 59.44 Quite High
Arthritis 2 33.56 Quite Low
Dysuria 2 26.48 Quite Low
Inflammation 19 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 21 86.92 High High
Edema 4 85.76 High High
Bacterial Infection 2 82.72 Quite High
Disease 42 63.76 Quite High
Depression 2 59.44 Quite High
Systemic Lupus Erythematosus 35 50.68 Quite High
Renal Disease 26 36.04 Quite Low
Eczema 2 34.48 Quite Low
Serositis 2 34.00 Quite Low
Arthritis 2 33.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It acts via three mechanisms: preventing the formation of the C3 convertase by binding to C4b; accelerating the natural decay of the classical pathway C3 convertase; and as a cofactor for the serine proteinase factor I in the proteolytic inactivation of C4b, which prevents the formation of the C3 convertase.
Negative_regulation (preventing) of C3 Binding (formation) of
1) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.53 Pain Relevance 0.07
It acts via three mechanisms: preventing the formation of the C3 convertase by binding to C4b; accelerating the natural decay of the classical pathway C3 convertase; and as a cofactor for the serine proteinase factor I in the proteolytic inactivation of C4b, which prevents the formation of the C3 convertase.
Negative_regulation (prevents) of C3 Binding (formation) of
2) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.42 Pain Relevance 0.09
Weisman et al developed this molecule, which comprises the entire extracellular domain of CR1, and showed that it inhibited formation of C3 and C5 convertases in vivo (Weisman et al 1990a, 1990b).
Negative_regulation (inhibited) of C3 Binding (formation) of
3) Confidence 0.17 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0 Pain Relevance 0

General Comments

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