INT220909

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.03

lysosome (GNS, MMP13) peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13)

GNS (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 5 67.28 Osteoarthritis 15 5.00 Pain 3 5.00 Analgesic 2 5.00 Inflammation 2 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 15 5.00 Pain 3 5.00 INFLAMMATION 2 5.00 Hyperplasia 1 5.00 Necrosis 1 5.00 Cancer 1 5.00 Arthropathy 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Consistent with quantitative real-time PCR findings, the ELISA assay demonstrated that levels of MMP-1 and MMP-13 protein secreted into the media were significantly decreased by 10 mmol/l glucosamine (P < 0.05; Figure 1c,d).

glucosamine Negative_regulation (decreased) of Gene_expression (levels) of MMP-13

1) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0.03

General Comments

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